CancerGrief.com

August 19, 2008 Cancer for College E-NEWS OUR LATEST STORIES OF HOPE AND INSPIRATION Quick Links Cancer for College has turned our story into a beautiful magazine that chronicles how we were formed, our own struggles with cancer and the great things our scholarship recipients are doing with the help of our program. Please take the time to read through it. Download it here. Our Sponsors GET COMPETITIVE: Cancer for College Launches its 2008 Online Fundraiser SHARE OUR STORY WITH FRIENDS, FAMILY AND COLLEAGUES.  THE BIGGEST FUNDRAISERS WILL BE HONORED BY WILL FERRELL HIMSELF With Cancer for College growing in ways we couldn’t have ever imagined, we constantly have to look for new and exciting ways to keep our fundraising options open. Once again this year, we will kick-off our Online Fundraising Event through our website.  It is a way for you to share with friends, family and colleagues about the mission of Cancer for College and your participation in our event. Set up your own online fundraising web site using the simple template we have provided and send the link to everyone you think might be interested in our mission of providing college scholarships to cancer survivors and amputees.  Click here to set-up your site.  You can either use your username and password from tournament registration or simply make up a new one.  It’s very easy. The biggest fundraisers this year will be recognized by Will Ferrell at the 15th Annual Cancer form College Golf CLassic and Live Auction on September 19th at the Rancho Bernardo Inn. Last year, we raised nearly $12,000 through the online fundraiser.  Our goal this year is to raise $16,000, enough to fully fund one perpetual scholarship. GOOD LUCK!!! - CLICK HERE TO SET UP YOUR FUNDRAISING SITE! CANCER FOR COLLEGE A TRIUMPH SCHOLARSHIP FOUNDATION 1345 SPECIALTY DRIVE, SUITE E VISTA, CALIFORNIA 92081 760.599.5096 info@cancerforcollege.org www.cancerforcollege.org There is a link below to update your profile/e-mail.  Please take a moment to make sure our contact information is accurate for you so that you don’t miss any important announcements from Cancer for College.

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August 2008

A Message from Dr. Love The Data Arrive The most exciting part of conducting a research study is when you start to get data. This is when you can begin thinking big and forming hypotheses to fit what you have found. And this is precisely what Dr. Dixie Mills, our FoundationÂ’s medical director, our students, and I have been doing this summer! As you may recall, in 2007 we received a grant from the Avon Foundation to study the physiology of the resting breast—the first-ever study to look at what happens in the non-breastfeeding breast. (YouÂ’d think that by the 21st century weÂ’d already have a full understanding of the basic anatomy and physiology of the breast—but we donÂ’t.) We know quite a bit about the breastfeeding breast. The breast is magical—it has the ability to make blood into milk. And as any woman who has breastfed knows, if you drink a glass of wine, your baby will get sleepy, whereas if you eat spicy food they will be up all night. And itÂ’s not just what a woman eats that gets into her breast milk. Studies have found pesticides, nicotine, and other chemicals in a motherÂ’s breast milk. But what about when a woman is not breastfeeding? Do these substances also get passed into a woman’s breast fluid? To answer this question, we decided to see how long it takes certain substances to get into the breast fluid of women who are not breastfeeding. What we have found so far is very interesting. And since no one has ever done this type of research before, what we have found is, for us, just like finding water on Mars! MORE> Hot Topics Red Meat Eaten During Adolescence May Increase Risk of Premenopausal Breast Cancer A new study adds more evidence to the belief that eating red meat may increase breast cancer risk. Breast tissue begins to develop when a girl enters puberty. But the breast ducts do not fully form until after a first pregnancy. This had led breast cancer researchers to hypothesize that environmental exposures to carcinogens that occur during adolescence—when the breast is undergoing significant changes—have the potential to increase a womanÂ’s breast cancer risk later in life. For this study, investigators at the Harvard School of Public Health used data obtained from the 116,600 women enrolled in the Nurses’ Health Study II. They found that the women who ate the most red meat during high school were between 30% and 40% more likely to be diagnosed with breast cancer than were the women who ate the least red meat. But there are inherent problems in observational studies, like this one, that could impact the findings. MORE > Cause for Love Make Dr. Love’s 60th Birthday the “Year of Love” In celebration of Dr. Love’s 60th birthday, and in recognition of her pioneering work as a breast cancer surgeon, advocate, and researcher, the Foundation invites you to join us in the Year of Love. Our goal is to raise $600,000 in honor of Dr. Love and her work. With your help, we can do it! When you donate in Dr. Love’s honor, you’ll have the opportunity to send her a personal message, which will be included on her virtual birthday card on our website. Donations in honor of Dr. Love can be made throughout 2008. Make a donation and send your birthday wishes. Point Your Browser to GoodSearch.com & GoodShop.com to Support the Foundation What if the Dr. Susan Love Research Foundation earned a penny every time you searched the Internet? And what if a percentage of every purchase you made online went to support our cause? Well, now it can! GoodSearch.com is a new Yahoo-powered search engine that donates half of its advertising revenue, about a penny per search, to the charities its users designate. Just go to www.goodsearch.com and be sure to enter “Dr. Susan Love Research Foundation” as the charity you want to support. GoodShop.com is a new online shopping mall that donates up to 37 percent of each purchase to the Dr. Susan Love Research Foundation! Hundreds of great stores including Amazon, Target, Gap, Best Buy, ebay, Macy’s, and Barnes & Noble have teamed up with GoodShop and every time you place an order, you’ll be supporting the Foundation. Spread the word! Research Update Yield in Asian-American Women: A Pilot Study We are looking to recruit 30 Asian-American women in the next month to help us with our Breast Fluid Test Project. We would like you to come in to our office in Santa Monica for about an hour and try different methods of obtaining “nipple aspirate fluid”. Some women can just squeeze their nipples and fluid comes out, others need to massage their breasts for several minutes then squeeze or use warm heat on the breast. Asian and Asian-American women yield the lowest NAF of any group and in preparation for a larger study in China we hope to identify the easiest and best way do to this. We can compensate women $50 for their time. Please email research@dslrf.org or call 1-866-569-0388 for more information. Women Needed for Groundbreaking DCIS Study The Foundation is looking for 30 Californian women who have been diagnosed recently with ductal carcinoma in situ (DCIS) to take part in a groundbreaking new research project that involves injecting a small amount of a chemotherapy drug into the affected breast duct. Study participants will then have their DCIS surgery four to six weeks later. The breast tissue collected during the surgery will be carefully examined to see the effects of the drug on the DCIS. If the study successfully shows that the drug has an impact on the DCIS, it could lead to a nationwide clinical trial of intraductal therapy for DCIS. This research project, which was funded by the California Breast Cancer Research Program, is being conducted in collaboration with Ellen Mahoney, MD, and the Humboldt Community Breast Heath Project. Research participants will need to travel to Eureka, Calif., for the treatment and the surgery. Please call Ashley Casano at (310) 230-1712, Ext. 32, or send her an email for more information. © 2006-2008 Dr. Susan Love Research Foundation All rights reserved Did You Know? The best way to minimize hot flashes when you stop taking hormones to treat menopausal symptoms is to taper off gradually over several months. MORE > Your Questions What is Ki-67? An antigen is a protein that sits on the surface of a cell and stimulates the production of an antibody. Ki-67 is an antibody marker to a tumor antigen that can be found in breast cancer cells. MORE > Stories of Courage Teresa Allen On April 15, 2008, I was preparing to go back to work after being off for a week with bronchitis. I was rubbing the middle of my chest, where I was sore from coughing, and happened to feel a hard ridge along my sternum. Initially, I thought it was from coughing. But when I sat up, it fell into my left breast. My heart sank. MORE >

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CCR Translations
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Targets of Tumor Immunity After Allogeneic Hematopoietic Stem Cell Transplantation
Yishay Ofran and Jerome Ritz
Clin Cancer Res 2008;14 4997-4999
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/4997

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Molecular Pathways
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Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics
Alain C. Mita, Monica M. Mita, Steffan T. Nawrocki, and Francis J. Giles
Clin Cancer Res 2008;14 5000-5005
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5000

Clinical-Translational Approaches to the Nm23-H1 Metastasis Suppressor
Patricia S. Steeg, Christine E. Horak, and Kathy D. Miller
Clin Cancer Res 2008;14 5006-5012
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5006

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Review
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Circulating Tumor Cells and Bone Marrow Micrometastasis
Catherine Alix-Panabières, Sabine Riethdorf, and Klaus Pantel
Clin Cancer Res 2008;14 5013-5021
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5013

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Human Cancer Biology
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Overexpression of Stromal Cell–Derived Factor 1 and Its Receptor CXCR4 Induces Autocrine/Paracrine Cell Proliferation in Human Pituitary Adenomas
Federica Barbieri, Adriana Bajetto, Ralf Stumm, Alessandra Pattarozzi, Carola Porcile, Gianluigi Zona, Alessandra Dorcaratto, Jean-Louis Ravetti, Francesco Minuto, Renato Spaziante, Gennaro Schettini, Diego Ferone, and Tullio Florio
Clin Cancer Res 2008;14 5022-5032
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5022

Midkine Enhances Soft-Tissue Sarcoma Growth: A Possible Novel Therapeutic Target
Zeming Jin, Guy Lahat, Borys Korchin, Theresa Nguyen, Quan-Sheng Zhu, Xuemei Wang, Alexander J. Lazar, Jonathan Trent, Raphael E. Pollock, and Dina Lev
Clin Cancer Res 2008;14 5033-5042
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5033

High Expression of Neuropeptide Y1 Receptors in Ewing Sarcoma Tumors
Meike Körner, Beatrice Waser, and Jean Claude Reubi
Clin Cancer Res 2008;14 5043-5049
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5043

Nonredundant Functions for Tumor Protein D52-Like Proteins Support Specific Targeting of TPD52
Mona Shehata, Ivan Bièche, Rose Boutros, Judith Weidenhofer, Susan Fanayan, Lisa Spalding, Nikolajs Zeps, Karen Byth, Robert K. Bright, Rosette Lidereau, and Jennifer A. Byrne
Clin Cancer Res 2008;14 5050-5060
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5050

COOH-Terminal Truncated HBV X Protein Plays Key Role in Hepatocarcinogenesis
Ning-Fang Ma, Sze Hang Lau, Liang Hu, Dan Xie, Jun Wu, Jun Yang, Yi Wang, Meng-Chao Wu, Jackie Fung, Xueyan Bai, Chi-Hung Tzang, Li Fu, Mengsu Yang, Yan An Su, and Xin-Yuan Guan
Clin Cancer Res 2008;14 5061-5068
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5061

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Cancer Therapy: Preclinical
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Vascular Endothelial Growth Factor Receptor-1 Contributes to Resistance to Anti–Epidermal Growth Factor Receptor Drugs in Human Cancer Cells
Roberto Bianco, Roberta Rosa, Vincenzo Damiano, Gennaro Daniele, Teresa Gelardi, Sonia Garofalo, Valeria Tarallo, Sandro De Falco, Davide Melisi, Roberto Benelli, Adriana Albini, Anderson Ryan, Fortunato Ciardiello, and Giampaolo Tortora
Clin Cancer Res 2008;14 5069-5080
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5069

Vandetanib Inhibits Growth of Adenoid Cystic Carcinoma in an Orthotopic Nude Mouse Model
Sungweon Choi, Daisuke Sano, Melvina Cheung, Mei Zhao, Samar A. Jasser, Anderson J. Ryan, Li Mao, Wan-Tao Chen, Adel K. El-Naggar, and Jeffrey N. Myers
Clin Cancer Res 2008;14 5081-5089
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5081

Perifosine Synergistically Enhances TRAIL-Induced Myeloma Cell Apoptosis via Up-Regulation of Death Receptors
Ebenezer David, Rajni Sinha, Jing Chen, Shi-Yong Sun, Jonathan L. Kaufman, and Sagar Lonial
Clin Cancer Res 2008;14 5090-5098
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5090

Enhanced Antitumor Therapy by Inhibition of p21waf1 in Human Malignant Mesothelioma
Raffaella Lazzarini, Simona Moretti, Sara Orecchia, Pier-Giacomo Betta, Antonio Procopio, and Alfonso Catalano
Clin Cancer Res 2008;14 5099-5107
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5099

Multimodality Therapy: Potentiation of High Linear Energy Transfer Radiation with Paclitaxel for the Treatment of Disseminated Peritoneal Disease
Diane E. Milenic, Kayhan Garmestani, Erik D. Brady, Kwamena E. Baidoo, Paul S. Albert, Karen J. Wong, Joseph Flynn, and Martin W. Brechbiel
Clin Cancer Res 2008;14 5108-5115
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5108

Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells
Callum M. Sloss, Fang Wang, Rong Liu, Lijun Xia, Michael Houston, David Ljungman, Michael A. Palladino, and James C. Cusack, Jr.
Clin Cancer Res 2008;14 5116-5123
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5116

Effect of Rapamycin Alone and in Combination with Sorafenib in an Orthotopic Model of Human Hepatocellular Carcinoma
Zheng Wang, Jian Zhou, Jia Fan, Shuang-Jian Qiu, Yao Yu, Xiao-Wu Huang, and Zhao-You Tang
Clin Cancer Res 2008;14 5124-5130
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5124

Checkpoint Kinase 1 Down-Regulation by an Inducible Small Interfering RNA Expression System Sensitized In vivo Tumors to Treatment with 5-Fluorouracil
Monica Ganzinelli, Laura Carrassa, Francesca Crippa, Michele Tavecchio, Massimo Broggini, and Giovanna Damia
Clin Cancer Res 2008;14 5131-5141
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5131

The Combination of Epidermal Growth Factor Receptor Inhibitors with Gemcitabine and Radiation in Pancreatic Cancer
Meredith A. Morgan, Leslie A. Parsels, Laura E. Kollar, Daniel P. Normolle, Jonathan Maybaum, and Theodore S. Lawrence
Clin Cancer Res 2008;14 5142-5149
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5142

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Imaging, Diagnosis, Prognosis
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Tumor Cell and Tumor Vasculature Expression of B7-H3 Predict Survival in Clear Cell Renal Cell Carcinoma
Paul L. Crispen, Yuri Sheinin, Timothy J. Roth, Christine M. Lohse, Susan M. Kuntz, Xavier Frigola, R. Houston Thompson, Stephen A. Boorjian, Haidong Dong, Bradley C. Leibovich, Michael L. Blute, and Eugene D. Kwon
Clin Cancer Res 2008;14 5150-5157
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5150

Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes
Christine Desmedt, Benjamin Haibe-Kains, Pratyaksha Wirapati, Marc Buyse, Denis Larsimont, Gianluca Bontempi, Mauro Delorenzi, Martine Piccart, and Christos Sotiriou
Clin Cancer Res 2008;14 5158-5165
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5158

Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas
Amy B. Heimberger, Mohamed Abou-Ghazal, Chantal Reina-Ortiz, David S. Yang, Wei Sun, Wei Qiao, Nobuyoshi Hiraoka, and Gregory N. Fuller
Clin Cancer Res 2008;14 5166-5172
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5166

Predicting Clinical Outcome through Molecular Profiling in Stage III Melanoma
Thomas John, Michael A. Black, Tumi T. Toro, Debbie Leader, Craig A. Gedye, Ian D. Davis, Parry J. Guilford, and Jonathan S. Cebon
Clin Cancer Res 2008;14 5173-5180
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5173

Deletion of 1p32-p36 Is the Most Frequent Genetic Change and Poor Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands
Pulivarthi H. Rao, Diana Roberts, Yi-Jue Zhao, Diana Bell, Charles P. Harris, Randal S. Weber, and Adel K. El-Naggar
Clin Cancer Res 2008;14 5181-5187
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5181

HER3 Is a Determinant for Poor Prognosis in Melanoma
Markus Reschke, Daniela Mihic-Probst, Edward Htun van der Horst, Pjotr Knyazev, Peter J. Wild, Markus Hutterer, Stefanie Meyer, Reinhard Dummer, Holger Moch, and Axel Ullrich
Clin Cancer Res 2008;14 5188-5197
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5188

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome
Richard W. Tothill, Anna V. Tinker, Joshy George, Robert Brown, Stephen B. Fox, Stephen Lade, Daryl S. Johnson, Melanie K. Trivett, Dariush Etemadmoghadam, Bianca Locandro, Nadia Traficante, Sian Fereday, Jillian A. Hung, Yoke-Eng Chiew, Izhak Haviv, Australian Ovarian Cancer Study Group, Dorota Gertig, Anna deFazio, and David D.L. Bowtell
Clin Cancer Res 2008;14 5198-5208
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5198

Gefitinib Induction of In vivo Detectable Signals by Bcl-2/Bcl-xL Modulation of Inositol Trisphosphate Receptor Type 3
Antonella Zannetti, Francesca Iommelli, Rosa Fonti, Angela Papaccioli, Jvana Sommella, Anna Lettieri, Giuseppe Pirozzi, Roberto Bianco, Giampaolo Tortora, Marco Salvatore, and Silvana Del Vecchio
Clin Cancer Res 2008;14 5209-5219
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5209

Prognostic Effect of Epithelial and Stromal Lymphocyte Infiltration in Non–Small Cell Lung Cancer
Khalid I. Al-Shibli, Tom Donnem, Samer Al-Saad, Magnus Persson, Roy M. Bremnes, and Lill-Tove Busund
Clin Cancer Res 2008;14 5220-5227
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5220

Nuclear and Cytoplasmic Expression of ERβ1, ERβ2, and ERβ5 Identifies Distinct Prognostic Outcome for Breast Cancer Patients
Abeer M. Shaaban, Andrew R. Green, Suchita Karthik, Yalda Alizadeh, Thomas A. Hughes, Lynn Harkins, Ian O. Ellis, John F. Robertson, Emma C. Paish, Philippa T.K. Saunders, Nigel P. Groome, and Valerie Speirs
Clin Cancer Res 2008;14 5228-5235
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5228

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Cancer Therapy: Clinical
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Intratumoral Metabolic Heterogeneity of Cervical Cancer
Elizabeth A. Kidd and Perry W. Grigsby
Clin Cancer Res 2008;14 5236-5241
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5236

CTLA-4 Blockade Confers Lymphocyte Resistance to Regulatory T-Cells in Advanced Melanoma: Surrogate Marker of Efficacy of Tremelimumab?
Cédric Ménard, François Ghiringhelli, Stephan Roux, Nathalie Chaput, Christine Mateus, Ursula Grohmann, Sophie Caillat-Zucman, Laurence Zitvogel, and Caroline Robert
Clin Cancer Res 2008;14 5242-5249
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5242

Phase II Study of Combination Therapy with S-1 and Irinotecan for Advanced Non–Small Cell Lung Cancer: West Japan Thoracic Oncology Group 3505
Isamu Okamoto, Takashi Nishimura, Masaki Miyazaki, Hiroshige Yoshioka, Akihito Kubo, Koji Takeda, Noriyuki Ebi, Shunichi Sugawara, Nobuyuki Katakami, Masahiro Fukuoka, and Kazuhiko Nakagawa
Clin Cancer Res 2008;14 5250-5254
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5250

An Initial Report of a Radiation Dose-Escalation Trial in Patients with One to Five Sites of Metastatic Disease
Joseph K. Salama, Steven J. Chmura, Neil Mehta, Kamil M. Yenice, Walter M. Stadler, Everett E. Vokes, Daniel J. Haraf, Samuel Hellman, and Ralph R. Weichselbaum
Clin Cancer Res 2008;14 5255-5259
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5255

C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8+ Cytotoxic T Cells from Renal Cell Carcinoma Patients
Scott S. Tykodi, Nobuharu Fujii, Nathalie Vigneron, Sharon M. Lu, Jeffrey K. Mito, Maureen X. Miranda, Jeffrey Chou, Lilien N. Voong, John A. Thompson, Brenda M. Sandmaier, Peter Cresswell, Benoît Van den Eynde, Stanley R. Riddell, and Edus H. Warren
Clin Cancer Res 2008;14 5260-5269
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5260

Phenotype and Functional Characterization of Long-term gp100-Specific Memory CD8+ T Cells in Disease-Free Melanoma Patients Before and After Boosting Immunization
Edwin B. Walker, Daniel Haley, Ulf Petrausch, Kevin Floyd, William Miller, Nelson Sanjuan, Greg Alvord, Bernard A. Fox, and Walter J. Urba
Clin Cancer Res 2008;14 5270-5283
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5270

Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant
Robert J. Lechleider, Philip M. Arlen, Kwong-Yok Tsang, Seth M. Steinberg, Junko Yokokawa, Vittore Cereda, Kevin Camphausen, Jeffrey Schlom, William L. Dahut, and James L. Gulley
Clin Cancer Res 2008;14 5284-5291
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5284

Clinical and Immunologic Results of a Phase II Trial of Sequential Imiquimod and Photodynamic Therapy for Vulval Intraepithelial Neoplasia
Ursula Winters, Sai Daayana, John T. Lear, Anne E. Tomlinson, Eyad Elkord, Peter L. Stern, and Henry C. Kitchener
Clin Cancer Res 2008;14 5292-5299
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5292

Analysis of Competing Risks of Causes of Death and their Variation Over Different Time Periods in Hodgkin’s Disease
Mariano Provencio, Isabel Millán, Pilar España, Antonio C. Sánchez, José J. Sánchez, Blanca Cantos, Juan A. Vargas, Carmen Bellas, Vanesa García, Pilar Sabin, and Félix Bonilla
Clin Cancer Res 2008;14 5300-5305
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/16/5300

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Letters to the Editor
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Cytoplasmic MUC1 in PanIN-1
Jacques Bara and Marie-Elisabeth Forgue-Lafitte
Clin Cancer Res 2008;14 5306
http://clincancerres.aacrjournals.org/cgi/content/full/14/16/5306

Reply to the Letter to the Editor by Bara, et al
David V. Gold
Clin Cancer Res 2008;14 5306-5307
http://clincancerres.aacrjournals.org/cgi/content/full/14/16/5306-a

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Corrections
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Correction: Article on Diagnostic Markers for Ovarian Cancer
Clin Cancer Res 2008;14 5308
http://clincancerres.aacrjournals.org/cgi/content/full/14/16/5308

Correction: Article on Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide
Clin Cancer Res 2008;14 5308
http://clincancerres.aacrjournals.org/cgi/content/full/14/16/5308-a

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Editors’ Note
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Introducing CCR Translations
Carlos L. Arteaga and Jerome Ritz
Clin Cancer Res 2008;14 4681
http://clincancerres.aacrjournals.org/cgi/content/full/14/15/4681

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CCR Translations
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Moving Toward Individualized Cancer Therapies
Giovanni Tonon and Kenneth C. Anderson
Clin Cancer Res 2008;14 4682-4684
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4682

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Perspectives
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Erythropoiesis-Stimulating Agent Use in Cancer: Preclinical and Clinical Perspectives
Murat O. Arcasoy
Clin Cancer Res 2008;14 4685-4690
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4685

The Genetics of Castration-Resistant Prostate Cancer: What Can the Germline Tell Us?
Nima Sharifi, William L. Dahut, and William D. Figg
Clin Cancer Res 2008;14 4691-4693
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4691

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Human Cancer Biology
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Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression
Emily C. Brantley, L. Burton Nabors, G. Yancey Gillespie, Youn-Hee Choi, Cheryl Ann Palmer, Keith Harrison, Kevin Roarty, and Etty N. Benveniste
Clin Cancer Res 2008;14 4694-4704
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4694

Human Papillomavirus Type 16/18 Up-Regulates the Expression of Interleukin-6 and Antiapoptotic Mcl-1 in Non–Small Cell Lung Cancer
Ya-Wen Cheng, Huei Lee, Ming-Yuh Shiau, Tzu-Chin Wu, Tsung-Teng Huang, and Yih-Hsin Chang
Clin Cancer Res 2008;14 4705-4712
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4705

OPG Is Regulated by β-Catenin and Mediates Resistance to TRAIL-Induced Apoptosis in Colon Cancer
Enrico N. De Toni, Susanne E. Thieme, Andreas Herbst, Andrea Behrens, Petra Stieber, Andreas Jung, Helmut Blum, Burkhard Göke, and Frank T. Kolligs
Clin Cancer Res 2008;14 4713-4718
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4713

Delineation of TMPRSS2-ERG Splice Variants in Prostate Cancer
Ying Hu, Albert Dobi, Taduru Sreenath, Christopher Cook, Atekelt Y. Tadase, Lakshmi Ravindranath, Jennifer Cullen, Bungo Furusato, Yongmei Chen, Rajesh L. Thangapazham, Ahmed Mohamed, Chen Sun, Isabell A. Sesterhenn, David G. McLeod, Gyorgy Petrovics, and Shiv Srivastava
Clin Cancer Res 2008;14 4719-4725
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4719

Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Michael L. Nickerson, Erich Jaeger, Yangu Shi, Jeffrey A. Durocher, Sunil Mahurkar, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Anush Mukeria, Ivana Holcatova, Laura S. Schmidt, Jorge R. Toro, Sara Karami, Rayjean Hung, Gary F. Gerard, W. Marston Linehan, Maria Merino, Berton Zbar, Paolo Boffetta, Paul Brennan, Nathaniel Rothman, Wong-Ho Chow, Frederic M. Waldman, and Lee E. Moore
Clin Cancer Res 2008;14 4726-4734
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4726

Gene Expression Profiling of Papillary Thyroid Carcinoma Identifies Transcripts Correlated with BRAF Mutational Status and Lymph Node Metastasis
Gisele Oler, Cléber P. Camacho, Flávio C. Hojaij, Pedro Michaluart, Jr., Gregory J. Riggins, and Janete M. Cerutti
Clin Cancer Res 2008;14 4735-4742
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4735

Epithelial-Mesenchymal Transition in Cervical Cancer: Correlation with Tumor Progression, Epidermal Growth Factor Receptor Overexpression, and Snail Up-Regulation
Mei-Yi Lee, Cheng-Yang Chou, Ming-Jer Tang, and Meng-Ru Shen
Clin Cancer Res 2008;14 4743-4750
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4743

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Imaging, Diagnosis, Prognosis
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Prospective Study of the Accuracy of EGFR Mutational Analysis by High-Resolution Melting Analysis in Small Samples Obtained from Patients with Non–Small Cell Lung Cancer
Tomoya Fukui, Yuichiro Ohe, Koji Tsuta, Koh Furuta, Hiromi Sakamoto, Toshimi Takano, Hiroshi Nokihara, Noboru Yamamoto, Ikuo Sekine, Hideo Kunitoh, Hisao Asamura, Takaaki Tsuchida, Masahiro Kaneko, Masahiko Kusumoto, Seiichiro Yamamoto, Teruhiko Yoshida, and Tomohide Tamura
Clin Cancer Res 2008;14 4751-4757
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4751

Imaging of Urokinase-Type Plasminogen Activator Receptor Expression Using a 64Cu-Labeled Linear Peptide Antagonist by microPET
Zi-Bo Li, Gang Niu, Hui Wang, Lina He, Lily Yang, Michael Ploug, and Xiaoyuan Chen
Clin Cancer Res 2008;14 4758-4766
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4758

Pattern of Serum Autoantibodies Allows Accurate Distinction between a Tumor and Pathologies of the Same Organ
Nicole Ludwig, Andreas Keller, Nicole Comtesse, Stefanie Rheinheimer, Christian Pallasch, Ulrike Fischer, Klaus Fassbender, Wolf Ingo Steudel, Hans-Peter Lenhof, and Eckart Meese
Clin Cancer Res 2008;14 4767-4774
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4767

The Retinoblastoma Family Member pRb2/p130 Is an Independent Predictor of Survival in Human Soft Tissue Sarcomas
Valeria Masciullo, Ester Berardengo, Antonella Boglione, Alessandro Sgambato, Amelia Bernardi, Marco Forni, Alessandra Linari, Letizia Cito, Giovanni Scambia, Alessandro Comandone, and Antonio Giordano
Clin Cancer Res 2008;14 4775-4779
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4775

Prognostic Significance of CD55 Expression in Breast Cancer
Jun-ichiro Ikeda, Eiichi Morii, Yalan Liu, Ying Qiu, Naoto Nakamichi, Ryu Jokoji, Yasuo Miyoshi, Shinzaburo Noguchi, and Katsuyuki Aozasa
Clin Cancer Res 2008;14 4780-4786
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4780

Genetic Polymorphisms of Metastasis Suppressor Gene NME1 and Breast Cancer Survival
Shimian Qu, Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Hui Cai, Yu-Tang Gao, and Wei Zheng
Clin Cancer Res 2008;14 4787-4793
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4787

Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
Marcin Skrzypski, Ewa Jassem, Miquel Taron, Jose Javier Sanchez, Pedro Mendez, Witold Rzyman, Grazyna Gulida, Dan Raz, David Jablons, Mariano Provencio, Bartomeu Massuti, Imane Chaib, Laia Perez-Roca, Jacek Jassem, and Rafael Rosell
Clin Cancer Res 2008;14 4794-4799
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4794

T-Cell Coregulatory Molecule Expression in Urothelial Cell Carcinoma: Clinicopathologic Correlations and Association with Survival
Stephen A. Boorjian, Yuri Sheinin, Paul L. Crispen, Sara A. Farmer, Christine M. Lohse, Susan M. Kuntz, Bradley C. Leibovich, Eugene D. Kwon, and Igor Frank
Clin Cancer Res 2008;14 4800-4808
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4800

Quantitative Analysis of the Transrenal Excretion of Circulating EBV DNA in Nasopharyngeal Carcinoma Patients
K.C. Allen Chan, Sing F. Leung, Sze W. Yeung, Anthony T.C. Chan, and Y.M. Dennis Lo
Clin Cancer Res 2008;14 4809-4813
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4809

ASPM Is a Novel Marker for Vascular Invasion, Early Recurrence, and Poor Prognosis of Hepatocellular Carcinoma
Shih-Yeh Lin, Hung-Wei Pan, Shu-Hsiang Liu, Yung-Ming Jeng, Fu-Chang Hu, Shian-Yang Peng, Po-Lin Lai, and Hey-Chi Hsu
Clin Cancer Res 2008;14 4814-4820
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4814

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Cancer Therapy: Clinical
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Tumor Cell Gene Expression Changes Following Short-term In vivo Exposure to Single Agent Chemotherapeutics are Related to Survival in Multiple Myeloma
Bart Burington, Bart Barlogie, Fenghuang Zhan, John Crowley, and John D. Shaughnessy, Jr.
Clin Cancer Res 2008;14 4821-4829
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4821

K-Ras Mutations and Treatment Outcome in Colorectal Cancer Patients Receiving Exclusive Fluoropyrimidine Therapy
Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Mireille Francoual, Eric François, Patricia Formento, Nicole Renée, Pierre Laurent-Puig, Maurice Chazal, Daniel Benchimol, Jean-Robert Delpero, Christian Letoublon, Denis Pezet, Jean-François Seitz, and Gérard Milano
Clin Cancer Res 2008;14 4830-4835
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4830

A Phase I Trial of the Oral, Multikinase Inhibitor Sorafenib in Combination with Carboplatin and Paclitaxel
Keith T. Flaherty, Joan Schiller, Lynn M. Schuchter, Glenn Liu, David A. Tuveson, Maryann Redlinger, Chetan Lathia, Chenghua Xia, Oana Petrenciuc, Sunil R. Hingorani, Michael A. Jacobetz, Patricia A. Van Belle, David Elder, Marcia S. Brose, Barbara L. Weber, Mark R. Albertini, and Peter J. O’Dwyer
Clin Cancer Res 2008;14 4836-4842
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4836

Combination Chemotherapy and ALVAC-CEA/B7.1 Vaccine in Patients with Metastatic Colorectal Cancer
Howard L. Kaufman, Heinz-Josef Lenz, John Marshall, Deepti Singh, Chris Garett, Christine Cripps, Malcolm Moore, Margaret von Mehren, Richard Dalfen, William J. Heim, Robert M. Conry, Walter J. Urba, Al B. Benson, III, Maria Yu, Judy Caterini, Seunghee Kim-Schulze, Mark DeBenedette, Danielle Salha, Thorsten Vogel, Ileana Elias, and Neil L. Berinstein
Clin Cancer Res 2008;14 4843-4849
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4843

A Pilot Study of Consolidative Immunotherapy in Patients with High-Risk Pediatric Sarcomas
Crystal L. Mackall, Eunice H. Rhee, Elizabeth J. Read, Hanh M. Khuu, Susan F. Leitman, Donna Bernstein, Merertu Tesso, Lauren M. Long, David Grindler, Margret Merino, William Kopp, Maria Tsokos, Jay A. Berzofsky, and Lee J. Helman
Clin Cancer Res 2008;14 4850-4858
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4850

Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma
Jill A. Maxwell, Stewart P. Johnson, Roger E. McLendon, David W. Lister, Krystle S. Horne, Ahmed Rasheed, Jennifer A. Quinn, Francis Ali-Osman, Allan H. Friedman, Paul L. Modrich, Darell D. Bigner, and Henry S. Friedman
Clin Cancer Res 2008;14 4859-4868
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4859

Motexafin Lutetium-Photodynamic Therapy of Prostate Cancer: Short- and Long-Term Effects on Prostate-Specific Antigen
Hiral Patel, Rosemarie Mick, Jarod Finlay, Timothy C. Zhu, Elizabeth Rickter, Keith A. Cengel, S. Bruce Malkowicz, Stephen M. Hahn, and Theresa M. Busch
Clin Cancer Res 2008;14 4869-4876
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4869

Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Mutations Is Associated with Poor Gefitinib Treatment Response
Jenn-Yu Wu, Shang-Gin Wu, Chih-Hsin Yang, Chien-Hung Gow, Yih-Leong Chang, Chong-Jen Yu, Jin-Yuan Shih, and Pan-Chyr Yang
Clin Cancer Res 2008;14 4877-4882
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4877

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy
Dörthe Schaue, Begonya Comin-Anduix, Antoni Ribas, Li Zhang, Lee Goodglick, James W. Sayre, Annelies Debucquoy, Karin Haustermans, and William H. McBride
Clin Cancer Res 2008;14 4883-4890
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4883

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Cancer Therapy: Preclinical
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Efficacy of Systemically Administered Mutant Vesicular Stomatitis Virus (VSV51) Combined with Radiation for Nasopharyngeal Carcinoma
Nehad M. Alajez, Joseph D. Mocanu, Wei Shi, Marie C. Chia, Caroline J. Breitbach, Angela B.Y. Hui, Shane Knowles, John C. Bell, Pierre Busson, Kenzo Takada, Kwok-Wai Lo, Brian O’Sullivan, Pat Gullane, and Fei-Fei Liu
Clin Cancer Res 2008;14 4891-4897
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4891

Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor
Cheryl L-L. Chiang, Jonathan A. Ledermann, Egla Aitkens, Elizabeth Benjamin, David R. Katz, and Benjamin M. Chain
Clin Cancer Res 2008;14 4898-4907
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4898

Sorafenib Potently Inhibits Papillary Thyroid Carcinomas Harboring RET/PTC1 Rearrangement
Ying C. Henderson, Soon-Hyun Ahn, Ya’an Kang, and Gary L. Clayman
Clin Cancer Res 2008;14 4908-4914
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4908

Radiation-Mediated Up-Regulation of Gene Expression from Replication-Defective Adenoviral Vectors: Implications for Sodium Iodide Symporter Gene Therapy
Mohan Hingorani, Christine L. White, Shane Zaidi, Andrew Merron, Inge Peerlinck, Martin E. Gore, Christopher M. Nutting, Hardev S. Pandha, Alan A. Melcher, Richard G. Vile, Georges Vassaux, and Kevin J. Harrington
Clin Cancer Res 2008;14 4915-4924
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4915

Radiation Therapy with Tositumomab (B1) Anti-CD20 Monoclonal Antibody Initiates Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase–Dependent Cell Death that Overcomes Resistance to Apoptosis
Andrey Ivanov, Sergei Krysov, Mark S. Cragg, and Tim Illidge
Clin Cancer Res 2008;14 4925-4934
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4925

Suppression of Tumor Formation by a Cyclooxygenase-2 Inhibitor and a Peroxisome Proliferator-Activated Receptor Agonist in an In vivo Mouse Model of Spontaneous Breast Cancer
Aladdin Mustafa and Warren D. Kruger
Clin Cancer Res 2008;14 4935-4942
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4935

Human Mena+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines
Maria S. Pino, Michele Balsamo, Francesca Di Modugno, Marcella Mottolese, Massimo Alessio, Elisa Melucci, Michele Milella, David J. McConkey, Ulrike Philippar, Frank B. Gertler, Pier Giorgio Natali, and Paola Nisticò
Clin Cancer Res 2008;14 4943-4950
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4943

The Targeted Immunocytokine L19-IL2 Efficiently Inhibits the Growth of Orthotopic Pancreatic Cancer
Karola Wagner, Petra Schulz, Arne Scholz, Bertram Wiedenmann, and Andreas Menrad
Clin Cancer Res 2008;14 4951-4960
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4951

Silencing of Transforming Growth Factor-β1 In situ by RNA Interference for Breast Cancer: Implications for Proliferation and Migration In vitro and Metastasis In vivo
Lakisha D. Moore, Tatyana Isayeva, Gene P. Siegal, and Selvarangan Ponnazhagan
Clin Cancer Res 2008;14 4961-4970
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4961

Telomere Maintenance in Laser Capture Microdissection–Purified Barrett’s Adenocarcinoma Cells and Effect of Telomerase Inhibition In vivo
Masood A. Shammas, Aamer Qazi, Ramesh B. Batchu, Robert C. Bertheau, Jason Y.Y. Wong, Manjula Y. Rao, Madhu Prasad, Diptiman Chanda, Selvarangan Ponnazhagan, Kenneth C. Anderson, Christopher P. Steffes, Nikhil C. Munshi, Immaculata De Vivo, David G. Beer, Sergei Gryaznov, Donald W. Weaver, and Raj K. Goyal
Clin Cancer Res 2008;14 4971-4980
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4971

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Cancer Prevention and Susceptibility
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Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and Atorvastatin
Gang Lu, Hang Xiao, Hui You, Yong Lin, Huanyu Jin, Blake Snagaski, and Chung S. Yang
Clin Cancer Res 2008;14 4981-4988
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4981

CHEK2 1100delC Is a Susceptibility Allele for HNPCC-Related Colorectal Cancer
Marijke Wasielewski, Hans Vasen, Juul Wijnen, Maartje Hooning, Dennis Dooijes, Carli Tops, Jan G.M. Klijn, Hanne Meijers-Heijboer, and Mieke Schutte
Clin Cancer Res 2008;14 4989-4994
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/15/4989

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Corrections
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Correction: Article on Prognostic Implications of Stem Cell Marker Nestin and c-jun NH2- Terminal Kinases
Clin Cancer Res 2008;14 4995-4996
http://clincancerres.aacrjournals.org/cgi/content/full/14/15/4995

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August 2008
The new issue of CancerWise is now available online at www.cancerwise.org
Cancer Treatment May Cause Hearing Problems Nasopharyngeal cancer survivor Pamela Avery, 42, sustained hearing damage from chemotherapy and radiation but is able to hear now with the help of hearing aids. Read More Q&A: Hearing Loss From Cancer Treatment Answering questions about hearing loss caused by cancer treatment is Paul Gidley, M.D., associate professor in M. D. Anderson’s Department of Head and Neck Surgery. Read More Examine Health Insurance Before a Medical Crisis How do you know if your insurance coverage is adequate to cover a worst-case scenario, such as cancer? Connie Longuet, M. D. Anderson’s director of Patient Access Services, offers tips. Read More
Drug Helps Immune System Fight Cancer Therapy May Help Children Avoid Harsh Treatment Women Over 80 May Benefit From Mammograms Study First to Examine Screening in This Group Study Helps Define Cancer-Related Fatigue Similarities Found Among Patients Receiving Radiation
Hatha Yoga for Cancer Patients (1:54) Cancer Patients, Caregivers Find Creative Outlet Mind-Body Practices Video Archive
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(c) 2008 The University of Texas M. D. Anderson Cancer Center The material and content contained in CancerWise is for general health information only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Users of CancerWise should not rely exclusively on information provided in CancerWise for their own health needs. All specific medical questions should be presented to your own health care provider.

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This Month August Spotlight: Childhood Cancers Learn more about cancer in children and what Dana-Farber is doing to ease the burden of these young patients and their families, read related stories, ask our experts a question, and more. Explore Spotlight Monthly health quiz What are the risk factors for leukemia? Take the quiz Nutrition tip and recipe of the month Research on the effect of mustard seed in the diet highlights its ability to protect against carcinogens. Try Tofu and Corn Pasta, made with mustard seed. Get the recipe Ask the Nutritionist Online Stores Show your pride for Dana-Farber by sporting an item from our online stores. Choose from dozens of products with the Dana-Farber, Jimmy Fund, or individual event logo. Browse online stores How to Help A Chance for Kids® When you give $1 to benefit the Jimmy Fund at participating Burger King®, Blockbuster® and Olympia Sports locations, you’ll receive a promotion card with a guaranteed prize. Burger King Blockbuster Olympia Sports Jimmy Fund Golf Now in its 26th year, Jimmy Fund Golf is one of the largest organized golf programs in the U.S. Start a tournament and raise critical funds for cancer research while enjoying your favorite pastime. Start a tournament Mission Possible Campaign For 60 years, it has been our vision to eradicate cancer and the fear it engenders. Support Dana-Farber’s $1 billion campaign to conquer cancer. Mission Possible Campaign Make a gift Your gift to Dana-Farber helps us find cures for cancer and related diseases and makes a difference in the lives of those living with cancer. Make a gift Resources Cancer information Clinical trials News about Dana-Farber Jobs at Dana-Farber Request an appointment Nutrition Services Support Services Survivorship Dana-Farber Stories Donate platelets Feedback We are very interested in your thoughts about our newsletter. Please send us an e-mail. For more information about our programs and services, visit www.dana-farber.org or www.jimmyfund.org. Featured Story AUGUST 2008 Dana-Farber again ranked as New England’s top cancer center In the 2008 U.S.News & World Report hospital survey, Dana-Farber is again the highest ranked cancer hospital in New England and fifth in the country. This is the eighth straight year that Dana-Farber earned top ranking in New England and was among the top five centers nationally. Read more News 2007 Boston Red Sox/Jimmy Fund World Series Commemorative Ring Auction With the permission of Major League Baseball, Jostens, the creators of the 2007 Boston Red Sox World Series championship ring, has crafted a special edition of the 2007 ring exclusively for the Jimmy Fund. A true one-of-a-kind, this ring depicts the longest and most successful partnership between a professional sports team and a charity. Auction details PMC cyclists ride toward a cure Cyclists from 36 states and eight countries rode up to 190 miles across the Commonwealth in the 29th annual Pan-Massachusetts Challenge. Participants share their inspiration for why they ride. View the NECN video | Support a rider International consortium to catalog cancer’s secrets Cancer cells harbor so many mysteries that cancer is often described as a complex of distinct diseases. Now, leading research institutions in nine countries, including Dana-Farber, have joined forces to probe that complexity by uncovering the genetic changes that make cancer cells dangerous and elusive. Read more Patient-Family Resource Directory now available The new Patient-Family Resource Directory includes information for national and community organizations that provide practical and emotional support to patients, families and caregivers facing cancer. Use the directory to find help with financial and legal issues, resources for parents and young adults, advocacy groups and support networks, and more. View the directory For O’Neills, long wait is over It’s hard to find two scarier words than war and cancer. In the case of the O’Neill family of Brookline, both have been spoken daily for far too long. Now, however, they’ll be going on the back burner. Read their story Cindy Hale: ‘I ride for you’ One year after finishing chemotherapy and radiation, survivor Cindy Hale participated in the Pan-Massachusetts Challenge. Seven years later, she is still taking part in the event with her husband, family and friends. Read her story Save the Date Thursday and Friday, August 14 and 15, 2008 WEEI/NESN Jimmy Fund Radio-Telethon The Boston Red Sox, WEEI Sports Radio 850 AM, NESN, and the Jimmy Fund are once again teaming up for the 7th annual WEEI/NESN Jimmy Fund Radio-Telethon at Fenway Park. Call in your gift, bid on items in the All-Star Auction or buy tickets to a luncheon at Fenway Park to benefit the lifesaving mission of the Jimmy Fund at Dana-Farber. Support the Radio-Telethon | All-Star Auction | Lunch with legends Thursday, August 21, 2008 Centering Prayer Dana Chapel 12 - 12:30 p.m. Father Yaroslav of the Pastoral Care Department holds a weekly group prayer session for patients, family and staff. Each individual will have the opportunity to experience centering prayer through this exercise in faith, hope and selfless love. Sponsored by the Pastoral Care Department. For more information, call Nancy Gaudette at (617) 632-5778. Thursday, August 28, 2008 Introduction to Acupuncture DFCI, Dana 3 Pediatric Resource Room 10:30 - 11:30 a.m. Learn how acupuncture may help to relieve symptoms and improve quality of life. All pediatric patients, family members, friends, and staff are welcome to attend. Facilitated by Grant Hou, MB, MS, RTT, Lic.Ac. Preregistration is required. Call the Pediatric Resource Room at (617) 632-3900. Sunday, September 21, 2008 Boston Marathon® Jimmy Fund Walk presented by Hyundai Sign up for the Boston Marathon Jimmy Fund Walk and follow the historic route of the Boston Marathon in honor or memory of friends, family, co-workers, and Dana-Farber patients. Learn more For more information To view all of our upcoming seminars, workshops, and fundraising events, go to our Event Calendar. Learn mo © Dana-Farber Cancer Institute | 44 Binney Street | Boston, MA 02115 | www.dana-farber.org

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