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July 30, 2008 Cancer for College E-NEWS OUR LATEST STORIES OF HOPE AND INSPIRATION In This Issue Buy Your Mulligans Online Online Fundraiser Starts Special C4C Rate at RBI Up for Bid,,, Quick Links The #1 Comedy in America IN THEATERS NOW Catch Legendary Anchorman Ron Burgundy as he provides tips to 10 News Anchor Hal Clement SEE IT NOW Cancer for College has turned our story into a beautiful magazine that chronicles how we were formed, our own struggles with cancer and the great things our scholarship recipients are doing with the help of our program. Please take the time to read through it. Download it here. If You would like to receive a printed copy to share with a friend or a potential supporter of our cause, you may request one via e-mail to info@cancerforcollege.org Our Sponsors Dear Christine, Well, we have done it again. The 15th Annual Cancer for College Golf Classic is SOLD OUT, but DINNER TICKETS which includes the LIVE AUCTION hosted by WILL FERRELL and the AFTER-PARTY are STILL AVAILABLE. We will have upwards of 300 golfers out for a great day of fun and fundraising at the Rancho Bernardo Inn and the Country Club of Rancho Bernardo. We will be granting over $250,000 in scholarships this year and all 20 perpetual scholarship winners will be in attendance this year as well. Don’t feel left out. There are still tickets available for the dinner, live auction and after party hosted by Will Ferrell. Tickets are $175 and can be purchased online at www.cancerforcollege.org. We are also doing something new in offering the tournament mulligan package online this year for the first time. Register online before the tournament and you can get the package for $75. The same package will be $100 onsite the day of the event. Finally, we have once again created an individual fundraising site that each participant can customize and send out to their network of family and friends in an effort to make others aware of our cause. Last year we generated nearly $12,000 in additional funds. I’d like to see us fully fund a $16,000 perpetual scholarship this year. The top two fundraisers will earn a special prize and recognition from Will at the dinner. Please consider this simple but successful form of fundraising. Thanks for all your assistance and we hope to see you on the 19th. Sincerely, Craig Pollard Founder - Cancer for College A Triumph Scholarship Foundation Purchase “Mulligan Package” Online and Save on Fun and Games at the Tournament For the first time, the Cancer for College Golf Classic and Live Auction is offering the ability to purchase your MULLIGAN PACKAGE ONLINE through our web site. The Mulligan Package includes two (5) mulligans, 20 raffles tickets and entry into all contests including the hole-in-one, long drive, closest to the hole, straight drive and whatever else we can come up with. COST OF THE MULLIGAN PACKAGE ONLINE IS $75 100% of the proceeds go toward funding scholarships and is completely tax deductible. THE MULLIGAN PACKAGE WILL BE $100 THE DAY OF THE EVENT! To register visit our website at Cancer for College.org. Still Time for Sponsors… There are still plenty of sponsorship opportunities available at this year’s event ranging from table and hole sponsors to contest sponsors. Corporate sponsorships are available for as little as $250. For more details, click here. Get Competitive: Cancer for College Online Fundraiser Starts With Cancer for College growing in ways we couldn’t have ever imagined, we constantly have to look for new and exciting ways to keep our fundraising options open. Once again this year, we will kick-off our Online Fundraising Event through our website. It is a way for you to share with friends, family and colleagues about the mission of Cancer for College and your participation in our event. Set up your own online fundraising web site using the simple template we have provided and send the link to everyone you think might be interested in our mission of providing college scholarships to cancer survivors and amputees. Click here to set-up your site. You can either use your username and password from tournament registration or simply make up a new one. It’s very easy. Last year, we raised nearly $12,000 through the online fundraiser. Our goal is to raise $16,000, enough to fully fund one perpetual scholarship. DEADLINE TO REGISTER IS AUGUST 19 Rancho Bernardo Inn Offers Special Room Rates to C4C Event Partcipants Rancho Bernardo Inn has extended special block pricing on a limited amount of rooms for the Golf Classic at a rate of $225*. This rate is available September 18-20 and is offered on a first come, first served basis until the block is full. Please call reservations at 800-542-6092 to book your room no later than August 19 and identify yourself as a participant in the Cancer for College event to receive this rate. * tax and resort fees not included. WHAT’S UP FOR BID… DINNER TICKETS ARE STILL AVAILABLE FOR CANCER FOR COLLEGE’S SILENT AND LIVE AUCTIONS, PLUS AFTER-PARTY WITH THE MAR DELS The Silent and Live Auction will once again be a great part of the 2008 Golf Classic. Hosted by Will Ferrell and his wife Viveca Paulin, the Live Auction will have some amazing items up for bid including: First-Class Airfare and Accomodations at the Fairmont Hotel in Maui Channel 10 Behind the Scenes News Experience with anchorman Hal Clement 1-Year Membership at the Country Club of Rancho Bernardo Once in a lifetime golf experiences… Plus the Will Ferrell Fun Pack that could include anything from autographed memorabilia to the clothes off his back! Silent auction items include donations from Southern California professional sports franchises including the San Diego Padres and the Los Angeles Dodgers, plus local amusement parks, resorts, golf courses, restaraunts and more… If you have access to valuable auction items that we could use for the event, please contact Greg Flores at 760-599-5096 or greg@cancerforcollege.org. Don’t miss out on this great event. Tickets are still available online at cancerforcollege.org. for the Cancer for College Dinner, Live Auction and After-Party with music by the Mar Dels at the Rancho Bernardo Inn on September 19. CANCER FOR COLLEGE A TRIUMPH SCHOLARSHIP FOUNDATION 1345 SPECIALTY DRIVE, SUITE E VISTA, CALIFORNIA 92081 760.599.5096 info@cancerforcollege.org www.cancerforcollege.org There is a link below to update your profile/e-mail. Please take a moment to make sure our contact information is accurate for you so that you don’t miss any important announcements from Cancer for College.

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July 2008

A Message from Dr. Love Breast Self-Exam: What You Need to Know Last week, the esteemed Cochrane Collaboration, an international organization that evaluates medical research, released a new analysis of the large controlled studies that have looked at whether breast self-exam saves lives. Their conclusion: “Data from two large trials do not suggest a beneficial effect of screening by breast self-examination but do suggest increased harm in terms of increased numbers of benign lesions identified and an increased number of biopsies performed. At present, screening by breast self-examination or physical examination cannot be recommended.” Not surprisingly, the media were all over their new report. And as I read these news stories, and my quotes in them, I was frequently struck both by how many reporters got aspects of the story wrong and by what readers took away from the story, as evidenced by the calls we received and comments logged on media websites. I think this finding angered so many women because women have been taught for years that BSE is something that they can do to “prevent’ breast cancer. But BSE was never breast cancer “prevention.” By the time you can feel a lump, it’s been there for some time. It’s hard to let go of things we hold onto, especially something like BSE. We all know women who swear by it, who say that it was BSE that saved their lives. But as we learn more about cancer, and as we look at the research on BSE, we need to use this as an opportunity to examine what we’ve been taught about breast cancer and early detection. What this review really points to is the need for breast cancer research to shift its focus from early detection to finding the cause of breast cancer and how to prevent it. That’s the only way we are going to truly be able to make a difference in this disease. MORE> Hot Topics Screening Embryos for BRCA Mutations A British woman made news earlier this month when doctors reported that they had used in vitro fertilization (IVF) and pre-implantation diagnosis (PGD) to ensure that she would become pregnant with a baby that did not carry a BRCA mutation. PGD has been used in the United States for about 15 years to screen for mutations that cause breast, bowel, and eye cancers as well as other diseases. By screening the embryos, doctors are able to ensure that only embryos without a certain genetic condition or chromosomal problem are transferred back into the uterus. The technique is also used to screen for chromosomal problems in couples who have tried IVF repeatedly and failed to become pregnant. Woman who carry a BRCA mutation have a 50-85% of developing breast cancer. By using PGD to screen for the BRCA mutation, the couple has ensured that their daughter will not carry this particular mutation of the BRCA gene. This doesn’t mean that her risk has been eliminated. Rather, it will be the same as that of any other woman who does not carry the BRCA mutation. Also, we must keep in mind that there are other genes and mutations that we have not yet identified that could increase risk as well as carcinogens in the environment that we cannot control. As I said on the Today Show, I do not agree with this approach. Read more. Cause for Love A SurvivorÂ’s Guide for the Breast Cancer Journey The Foundation has partnered with RiverStone Journals, which has just released “A Survivor’s Guide for the Breast Cancer Journey: An Organizer and Handbook for the Newly Diagnosed.” The organizer provides a unique system to help women understand, plan, and record their journey through breast cancer, making it the perfect gift for you, a friend, or a loved one. The Foundation will receive $5.00 for each organizer purchased. The organizer can be purchased online at www.riverstonejournal.com Make Dr. Love’s 60th Birthday the “Year of Love” In celebration of Dr. Love’s 60th birthday, and in recognition of her pioneering work as a breast cancer surgeon, advocate, and researcher, the Foundation invites you to join us in the Year of Love. Our goal is to raise $600,000 in honor of Dr. Love and her work. With your help, we can do it! When you donate in Dr. Love’s honor, you’ll have the opportunity to send her a personal message, which will be included on her virtual birthday card on our website. Donations in honor of Dr. Love can be made throughout 2008. Make a donation and send your birthday wishes. Research Update Exploring an Efficient Way to Increase Nipple Aspirate Fluid Yield in Asian-American Women: A Pilot Study The Foundation is now recruiting 30 Asian-American women for our Breast Fluid Test Project. For this study, women will come to our office in Santa Monica for about one hour. The aim is to determine the best method for obtaining nipple aspirate fluid  (NAF). Three methods will be studied: women squeezing their own nipples; women massaging their breasts before squeezing; and women placing warm heat on their breasts before squeezing. Studies have found that Asian and Asian-American women yield the lowest NAF of any group and determining the most effective method is critical, as we will soon be starting a large NAF study in China. Volunteers will receive $50 for their time. Please email research@dslrf.org or call 1-866.569.0388 for more information. Women Needed for Groundbreaking DCIS Study The Foundation is looking for 30 Californian women who have recently been diagnosed with ductal carcinoma in situ (DCIS) to take part in a groundbreaking new research project that involves injecting a small amount of a chemotherapy drug into the affected breast duct. Study participants will then have their DCIS surgery four to six weeks later. The breast tissue collected during the surgery will be carefully examined to see the effects of the drug on the DCIS. If the study successfully shows that the drug has an impact on the DCIS, it could lead to a nationwide clinical trial of intraductal therapy for DCIS. This research project, which was funded by the California Breast Cancer Research Program, is being conducted in collaboration with Ellen Mahoney, MD, and the Humboldt Community Breast Heath Project. Research participants will need to travel to Eureka, Calif., for the treatment and the surgery. Please call Ashley Casano at (310) 230-1712 Ext. 32 or send her an email for more information. © 2006-2008 Dr. Susan Love Research Foundation All rights reserved Did You Know? The Genetic Information Nondiscrimination Act of 2008 makes it illegal for an insurer or employer to discriminate against someone because they carry a BRCA mutation. MORE > Your Questions I recently read that taking antidepressants can increase the risk of osteoporosis. Is this true? Researchers have found that there appears to be a connection between depression and osteoporosis, but it’s still not fully clear how the two are related. MORE > Stories of Courage Dana In 1992, at age 57, I was diagnosed with a small stage 1 infiltrating ductal carcinoma with one positive lymph node in the left breast. I had a lumpectomy, radiation, and chemotherapy. In December 2007, I was again diagnosed with breast cancer in the left breast. MORE >

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July 2008
We want your input! The M. D. Anderson public Web site (www.mdanderson.org) is being redesigned. Please take a few minutes to complete this short survey by Saturday, July 26, 2008. The new issue of CancerWise is now available online at www.cancerwise.org
Ancient Art of Acupuncture Helps Survivor Cope Ovarian cancer survivor Nannette Goddard has used acupuncture to find relief from cancer treatment side effects, such as neuropathy, a nerve disorder that caused bothersome tingling and numbness in her arms and legs. Read More Q&A: Acupuncture and Cancer Patients Acupuncture can help alleviate symptoms associated with cancer and cancer treatments, as well as conditions not related to cancer. Answering questions on the topic is Meide Liu, M.D., L.Ac., who treats about six cancer patients a day, five days a week at M. D. Anderson’s Place …of wellness. Read More Melanoma Is Not for Adults Only Some people have the misconception that melanoma occurs only in adults, but pediatric melanoma accounts for 1% of new melanoma cases in the United States. Melanoma survivor Chloe Fowlkes, 8, is among the 600 children diagnosed with the disease each year. Read More
Celebrex Slows Lung Cancer Development Precancerous Cells Respond to High Doses Iressa Shows Promise in Breast Cancer Drug and Hormonal Therapy Target Metastatic Disease Immune Dysfunction, Age Lower Survival Odds High Level of Protein Signals Danger in Melanoma
Qigong Slowly Calms Cancer Patients Facebook Gives Cancer Patients Support Mind-Body Practices Video Archive
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(c) 2008 The University of Texas M. D. Anderson Cancer Center The material and content contained in CancerWise is for general health information only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Users of CancerWise should not rely exclusively on information provided in CancerWise for their own health needs. All specific medical questions should be presented to your own health care provider.

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This Month July Spotlight: Cancer Health Disparities Learn more about cancer health disparities and what Dana-Farber is doing to help close the gap, view videos, read related stories, ask our experts a question, and more. Explore Spotlight Monthly health quiz What is the most common form of childhood cancer? Take the quiz Nutrition tip and recipe of the month Greek yogurt has about half the sugar of regular plain yogurt and twice the amount of protein. It’s also an excellent source of probiotics, or healthy bacteria that benefit our digestive system and overall health. Try Cucumber Dill Dressing. Get the recipe Ask the Nutritionist Online Stores Show your pride for Dana-Farber by sporting an item from our online stores. Choose from dozens of products with the Dana-Farber, Jimmy Fund, or individual event logo. Browse online stores How to Help Favor-ite thank yous In lieu of the standard party favor, consider a gift that carries a message of hope. Our Favors are perfect for both social and business occasions. Order Favors Step up to the plate Support your favorite baseball team and New England’s favorite charity by sporting the official Jimmy Fund/Boston Red Sox Massachusetts license plate on your vehicle. Order Sox plate Mission Possible Campaign For 60 years, it has been our vision to eradicate cancer and the fear it engenders. Support Dana-Farber’s $1 billion campaign to conquer cancer. Mission Possible Campaign Make a gift Your gift to Dana-Farber helps us find cures for cancer and related diseases and makes a difference in the lives of those living with cancer. Make a gift Resources Cancer information Clinical trials News about Dana-Farber Jobs at Dana-Farber Request an appointment Nutrition Services Support Services Survivorship Dana-Farber Stories Donate platelets Feedback We are very interested in your thoughts about our newsletter. Please send us an e-mail. For more information about our programs and services, visit www.dana-farber.org or www.jimmyfund.org. Featured Story JULY 2008 Researchers identify promising cancer drug target in prostate tumors Scientists at Dana-Farber report they have blocked the development of prostate tumors in cancer-prone mice by knocking out a molecular unit they described as a “powerhouse” that drives runaway cell growth. Read more News Study links vitamin D to colon cancer survival Patients diagnosed with colon cancer who had abundant vitamin D in their blood were less likely to die during a follow-up period than those who were deficient in the vitamin, according to a new study by scientists at Dana-Farber. Read more Platelets provide ‘ultimate gift’ Carlos Almas’ daughter Josephine was diagnosed with Hodgkin lymphoma in 1998, just as she was beginning her senior year of high school. Desperate to help, Almas asked his daughter’s Dana-Farber doctor what he could do. The reply: “Have you ever donated platelets?” Read more Dana-Farber launches national cancer education initiative Dana-Farber, a teaching affiliate of the Harvard Medical School, is launching a national continuing medical education (CME) course to bring the latest science and guidelines to community and sub-specialist oncologists engaged in patient care. Read more Survivor Story: Kelley Tuthill keeps in control through cancer Kelley Tuthill discovered integrative therapies as a way to help her juggle her breast cancer treatment with her roles as journalist, wife, and mother of two children under 5. Read her story Katelynn’s Ride evokes sweat and memories for survivor Prostate cancer survivor Robert Freedman shares a first-person account of his trek through the Connecticut River Valley of Western Massachusetts as part of Katelynn’s Ride to benefit the Jimmy Fund. Read his story Save the Date Saturday, July 12, 2008 Breast Cancer in Younger Women: A Forum for Patients and Survivors Fairmont Copley Plaza Hotel, Boston, Mass. 8 a.m. - 4.30 p.m. This forum includes lectures, break-outs, and panel discussions on an array of topics relevant to younger women with breast cancer and those close to them. For more information or to register, visit www.cancercare.harvard.edu or call (800) 553-3787. Tuesday, July 22, 2008 Qigong Class Jimmy Fund 836A/B Conference Room 4:30 - 6 p.m. Qigong coordinates different breathing patterns with various physical postures and motions of the body. This class is open to all adult patients, family members, and staff. Registration is required. To register or for more information, call the Zakim Center at (617) 632-3322. Thursday and Friday, August 14 and 15, 2008 WEEI/NESN Jimmy Fund Radio-Telethon The Boston Red Sox, WEEI Sports Radio 850 AM, NESN, and the Jimmy Fund are once again teaming up for the 7th annual WEEI/NESN Jimmy Fund Radio-Telethon at Fenway Park. Call in your gift to benefit the lifesaving mission of the Jimmy Fund at Dana-Farber. Support the Radio-Telethon Sunday, September 21, 2008 Boston Marathon® Jimmy Fund Walk presented by Hyundai Sign up for the Boston Marathon Jimmy Fund Walk and follow the historic route of the Boston Marathon in honor or memory of friends, family, co-workers, and Dana-Farber patients. Learn more For more information To view all of our upcoming seminars, workshops, and fundraising events, go to our Event Calendar. Learn more © Dana-Farber Cancer Institute | 44 Binney Street | Boston, MA 02115 | www.dana-farber.org

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		Week of July 6
	In This Issue: Better Way to Catch Ovarian Cancer Early? Is Hospice Care the Way to Go? New Diagnosis of Non-Hodgkin’s Lymphoma - Wait or Treat? Today’s Top Story 7 Myths About Cancer Pain Cancer pain isn’t a given. If you’ve got pain, there’s a lot you can do to ease it. Don’t suffer more than absolutely necessary. Learn more. Also see: Simple Steps to Help Deal With Daily Pain I Am a Survivor! Life After Colon Cancer Are You at Risk for Colon Cancer? Exploring Alternative Cancer Therapies Health News & Features Better Way to Catch Ovarian Cancer Early? A symptom checklist, combined with a blood test, can catch 80% of ovarian cancer in its earliest, most curable stages, a new study suggests. Also see: Can Your Job Help You Become Healthier? Does Smoking Marijuana Ease Pain? 1 in 7 Americans Lack Health Insurance Editor’s Picks Is Hospice Care the Way to Go? Are you caring for a loved one with cancer? Could a hospice help? Get the facts. Also see: Q&A: Dying at Home More Hot Topics on WebMD: Before Surgery: What Kind of Hysterectomy Is Right for You? Who Gets Breast Cancer and Who Survives NASCAR Star Jeff Gordon: Driven to Help Children Looking for Recipes? Get tantalizing taste delivered to your inbox when you get the free WebMD Healthy Cooking newsletter - sign up today! Members Are Talking From the Cancer Treatments & Advances message board: New Diagnosis of Non-Hodgkin’s Lymphoma - Wait or Treat? This member was recently diagnosed with non-Hodgkin’s lymphoma. Should she wait or treat it? Been there? What does the road ahead look like? From Our Sponsors Early Breast Cancer: Have You Explored All Your Treatment Options? If you are postmenopausal and have been taking Tamoxifen for 2 to 3 years after early-stage breast cancer, you have another treatment option. Learn about an adjuvant therapy that works differently than Tamoxifen, get an oncologist’s perspective and sign up for a free trial. Early Breast Cancer: Understanding Recurrence Risk Recurrence is the term used to describe the return of cancer following initial treatment. It’s perfectly normal to feel some fear about the possibility that breast cancer could recur. What can you do? Fight fear with information. Migraines: Real Patients, Real Perspectives Meet Joan: Even when she wasn’t having a migraine, she was worrying about when the next migraine was coming. Meet Corianne: She found out about a treatment, discussed it with her physician and worked out a treatment plan. Get advice from people like you who sought treatment and learned to manage their migraine attacks. Watch Migraine Videos Now. Newsletter Management You are subscribed as zephyrmyst69@aol.com. View and manage your WebMD newsletter preferences. Subscribe to more newsletters. Change/update your email address. To unsubscribe from this cholesterol management newsletter, send a blank email to cancer_news_unsub@health.webmd.com. To unsubscribe from ALL WebMD newsletters, send a blank email to unsub@health.webmd.com. WebMD Privacy Policy WebMD Office of Privacy 1175 Peachtree Street, Suite 2400, Atlanta, GA 30361 (c) 2008 WebMD, LLC. All rights reserved.	advertisement advertisement WebMD Shortcuts Cancer Health Center Member Support Group Ask the Expert News Center Boards & Events Home Page

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A new issue of Clinical Cancer Research is available online:
1 July 2008; Vol. 14, No. 13

The below Table of Contents is available online at: http://clincancerres.aacrjournals.org/content/vol14/issue13/?etoc

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CCR Drug Updates
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Nilotinib
Michael W. Deininger
Clin Cancer Res 2008;14 4027-4031
http://clincancerres.aacrjournals.org/cgi/content/full/14/13/4027

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Molecular Pathways
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DNA Damage Detection and Repair Pathways—Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy
Susan Ashwell and Sonya Zabludoff
Clin Cancer Res 2008;14 4032-4037
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4032

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Human Cancer Biology
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Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast
Michael J. Hayes, Dafydd Thomas, Agnieszka Emmons, Thomas J. Giordano, and Celina G. Kleer
Clin Cancer Res 2008;14 4038-4044
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4038

Overexpression of Jab1 in Hepatocellular Carcinoma and Its Inhibition by Peroxisome Proliferator-Activated Receptor Ligands In vitro and In vivo
Ming-Chuan Hsu, Chao-Cheng Huang, Hui-Chiu Chang, Tsung-Hui Hu, and Wen-Chun Hung
Clin Cancer Res 2008;14 4045-4052
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4045

Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas
Jian Huang, Michael A. Grotzer, Takuya Watanabe, Ekkehard Hewer, Torsten Pietsch, Stefan Rutkowski, and Hiroko Ohgaki
Clin Cancer Res 2008;14 4053-4058
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4053

Activation of Notch Signaling in a Xenograft Model of Brain Metastasis
Do-Hyun Nam, Hye-Min Jeon, Shiyeon Kim, Mi Hyun Kim, Young-Ju Lee, Min Su Lee, Hyunggee Kim, Kyeung Min Joo, Dong-Sup Lee, Janet E. Price, Sa Ik Bang, and Woong-Yang Park
Clin Cancer Res 2008;14 4059-4066
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4059

Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma
Alicia A. Tone, Heather Begley, Monika Sharma, Joan Murphy, Barry Rosen, Theodore J. Brown, and Patricia A. Shaw
Clin Cancer Res 2008;14 4067-4078
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4067

Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms
Daphne W. Bell, Brian W. Brannigan, Keitaro Matsuo, Dianne M. Finkelstein, Raffaella Sordella, Jeff Settleman, Tetsuya Mitsudomi, and Daniel A. Haber
Clin Cancer Res 2008;14 4079-4084
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4079

Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma
Shih-Hwa Chiou, Cheng-Chia Yu, Chi-Yang Huang, Shu-Chun Lin, Chung-Ji Liu, Tung-Hu Tsai, Shiu-Huey Chou, Chian-Shiu Chien, Hung-Hai Ku, and Jeng-Fan Lo
Clin Cancer Res 2008;14 4085-4095
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4085

Mitogen-Activated Protein Kinase Activation in Lung Adenocarcinoma: A Comparative Study between Ever Smokers and Never Smokers
Giannis Mountzios, David Planchard, Benjamin Besse, Pierre Validire, Philippe Girard, Christine Devisme, Meletios-Athanasios Dimopoulos, Jean-Charles Soria, and Pierre Fouret
Clin Cancer Res 2008;14 4096-4102
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4096

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Imaging, Diagnosis, Prognosis
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Molecular Subtypes of Breast Cancers Detected in Mammography Screening and Outside of Screening
Harri Sihto, Johan Lundin, Tiina Lehtimäki, Maarit Sarlomo-Rikala, Ralf Bützow, Kaija Holli, Liisa Sailas, Vesa Kataja, Mikael Lundin, Taina Turpeenniemi-Hujanen, Jorma Isola, Päivi Heikkilä, and Heikki Joensuu
Clin Cancer Res 2008;14 4103-4110
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4103

Osteopontin and Interleukin-8 Expression is Independently Associated with Prostate Cancer Recurrence
Daniel J. Caruso, Adrienne J.K. Carmack, Vinata B. Lokeshwar, Robert C. Duncan, Mark S. Soloway, and Bal L. Lokeshwar
Clin Cancer Res 2008;14 4111-4118
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4111

Clinical Significance of CXC Chemokine Receptor-4 and c-Met in Childhood Rhabdomyosarcoma
Francesca Diomedi-Camassei, Heather P. McDowell, Maria A. De Ioris, Stefania Uccini, Pierluigi Altavista, Giuseppe Raschellà, Roberta Vitali, Olga Mannarino, Luigi De Sio, Denis A. Cozzi, Alberto Donfrancesco, Alessandro Inserra, Francesco Callea, and Carlo Dominici
Clin Cancer Res 2008;14 4119-4127
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4119

Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers
Frank A. Sinicrope, Rafaela L. Rego, Nathan R. Foster, Stephen N. Thibodeau, Steven R. Alberts, Harold E. Windschitl, and Daniel J. Sargent
Clin Cancer Res 2008;14 4128-4133
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4128

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma
Raffaella Villa, Maria Grazia Daidone, Rosita Motta, Lorenza Venturini, Cinzia De Marco, Alberto Vannelli, Shigeki Kusamura, Dario Baratti, Marcello Deraco, Aurora Costa, Roger R. Reddel, and Nadia Zaffaroni
Clin Cancer Res 2008;14 4134-4140
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4134

Persistent Aberrations in Circulating DNA Integrity after Radiotherapy Are Associated with Poor Prognosis in Nasopharyngeal Carcinoma Patients
K.C. Allen Chan, Sing-Fai Leung, Sze-Wan Yeung, Anthony T.C. Chan, and Y.M. Dennis Lo
Clin Cancer Res 2008;14 4141-4145
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4141

In vivo Optical Molecular Imaging of Vascular Endothelial Growth Factor for Monitoring Cancer Treatment
Sung K. Chang, Imran Rizvi, Nicolas Solban, and Tayyaba Hasan
Clin Cancer Res 2008;14 4146-4153
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4146

Molecular Risk Stratification of Medulloblastoma Patients Based on Immunohistochemical Analysis of MYC, LDHB, and CCNB1 Expression
Talitha de Haas, Nancy Hasselt, Dirk Troost, Huib Caron, Mara Popovic, Lorna Zadravec-Zaletel, Wieslawa Grajkowska, Marta Perek, Maria-Chiara Osterheld, David Ellison, Frank Baas, Rogier Versteeg, and Marcel Kool
Clin Cancer Res 2008;14 4154-4160
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4154

Decreased Expression of Gastrokine 1 and the Trefoil Factor Interacting Protein TFIZ1/GKN2 in Gastric Cancer: Influence of Tumor Histology and Relationship to Prognosis
Steven F. Moss, Jin-Woo Lee, Edmond Sabo, Anna K. Rubin, John Rommel, Bruce R. Westley, Felicity E.B. May, John Gao, Patricia A. Meitner, Rose Tavares, and Murray B. Resnick
Clin Cancer Res 2008;14 4161-4167
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4161

Prognostic Effect of Basal-Like Breast Cancers Is Time Dependent: Evidence from Tissue Microarray Studies on a Lymph Node–Negative Cohort
Anna Marie Mulligan, Dushanthi Pinnaduwage, Shelley B. Bull, Frances P. O’Malley, and Irene L. Andrulis
Clin Cancer Res 2008;14 4168-4174
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4168

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Cancer Therapy: Clinical
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Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-B Subunits in Head and Neck Cancer
Clint Allen, Kunal Saigal, Liesl Nottingham, Pattatheyil Arun, Zhong Chen, and Carter Van Waes
Clin Cancer Res 2008;14 4175-4185
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4175

Effect of Food on the Pharmacokinetic Behavior of the Potent Oral Taxane BMS-275183
Linda E. Bröker, Manual Valdivieso, Mary Jo Pilat, Pamela DeLuca, Xiaofei Zhou, Susan Parker, Giuseppe Giaccone, and Patricia M. LoRusso
Clin Cancer Res 2008;14 4186-4191
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4186

Immunity Feedback and Clinical Outcome in Colon Cancer Patients Undergoing Chemoimmunotherapy with Gemcitabine + FOLFOX followed by Subcutaneous Granulocyte Macrophage Colony-Stimulating Factor and Aldesleukin (GOLFIG-1 Trial)
Pierpaolo Correale, Pierosandro Tagliaferri, Antonella Fioravanti, Maria Teresa Del Vecchio, Cinzia Remondo, Francesco Montagnani, Maria Saveria Rotundo, Chiara Ginanneschi, Ignazio Martellucci, Edoardo Francini, Maria Grazia Cusi, Pierfrancesco Tassone, and Guido Francini
Clin Cancer Res 2008;14 4192-4199
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4192

Randomized Crossover Pharmacokinetic Study of Solvent-Based Paclitaxel and nab-Paclitaxel
Erin R. Gardner, William L. Dahut, Charity D. Scripture, Jacquin Jones, Jeanny B. Aragon-Ching, Neil Desai, Michael J. Hawkins, Alex Sparreboom, and William D. Figg
Clin Cancer Res 2008;14 4200-4205
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4200

Efficacy and Safety of Two Doses of Pemetrexed Supplemented with Folic Acid and Vitamin B12 in Previously Treated Patients with Non-Small Cell Lung Cancer
Yuichiro Ohe, Yukito Ichinose, Kazuhiko Nakagawa, Tomohide Tamura, Kaoru Kubota, Nobuyuki Yamamoto, Susumu Adachi, Yoshihiro Nambu, Toshio Fujimoto, Yutaka Nishiwaki, Nagahiro Saijo, and Masahiro Fukuoka
Clin Cancer Res 2008;14 4206-4212
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4206

A Pharmacodynamic Model for the Time Course of Tumor Shrinkage by Gemcitabine + Carboplatin in Non–Small Cell Lung Cancer Patients
Lai-San Tham, Lingzhi Wang, Ross A. Soo, Soo-Chin Lee, How-Sung Lee, Wei-Peng Yong, Boon-Cher Goh, and Nicholas H.G. Holford
Clin Cancer Res 2008;14 4213-4218
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4213

Early Magnesium Reduction in Advanced Colorectal Cancer Patients Treated with Cetuximab Plus Irinotecan as Predictive Factor of Efficacy and Outcome
Bruno Vincenzi, Daniele Santini, Sara Galluzzo, Antonio Russo, Fabio Fulfaro, Marianna Silletta, Fabrizio Battistoni, Laura Rocci, Bruno Beomonte Zobel, Vincenzo Adamo, Giordano Dicuonzo, and Giuseppe Tonini
Clin Cancer Res 2008;14 4219-4224
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4219

Patients with ERCC1-Negative Locally Advanced Esophageal Cancers May Benefit from Preoperative Chemoradiotherapy
Min Kyoung Kim, Kyung-Ja Cho, Gui Young Kwon, Seung-Il Park, Yong Hee Kim, Jong Hoon Kim, Ho-Young Song, Ji Hoon Shin, Hwoon Yong Jung, Gin Hyug Lee, Kee Don Choi, and Sung-Bae Kim
Clin Cancer Res 2008;14 4225-4231
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4225

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Cancer Therapy: Preclinical
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Isopentenyl Pyrophosphate–Activated CD56+ T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma
Alan A.Z. Alexander, Amudhan Maniar, Jean-Saville Cummings, Andrew M. Hebbeler, Dan H. Schulze, Brian R. Gastman, C. David Pauza, Scott E. Strome, and Andrei I. Chapoval
Clin Cancer Res 2008;14 4232-4240
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4232

The Use of Chelated Radionuclide (Samarium-153-Ethylenediaminetetramethylenephosphonate) to Modulate Phenotype of Tumor Cells and Enhance T Cell–Mediated Killing
Mala Chakraborty, Elizabeth K. Wansley, Jorge A. Carrasquillo, Sarah Yu, Chang H. Paik, Kevin Camphausen, Michael D. Becker, William F. Goeckeler, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2008;14 4241-4249
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4241

Moscatilin Induces Apoptosis in Human Colorectal Cancer Cells: A Crucial Role of c-Jun NH2-Terminal Protein Kinase Activation Caused by Tubulin Depolymerization and DNA Damage
Tzu-Hsuan Chen, Shiow-Lin Pan, Jih-Hwa Guh, Cho-Hwa Liao, Der-Yi Huang, Chien-Chih Chen, and Che-Ming Teng
Clin Cancer Res 2008;14 4250-4258
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4250

Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy
Frank Friedlos, Panos Lehouritis, Lesley Ogilvie, Douglas Hedley, Lawrence Davies, David Bermudes, Ivan King, Jan Martin, Richard Marais, and Caroline J. Springer
Clin Cancer Res 2008;14 4259-4266
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4259

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells
Avalon Garcia, Yang Zheng, Chen Zhao, Alfredo Toschi, Judy Fan, Natalie Shraibman, H. Alex Brown, Dafna Bar-Sagi, David A. Foster, and Jack L. Arbiser
Clin Cancer Res 2008;14 4267-4274
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4267

EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer
Jussi P. Koivunen, Craig Mermel, Kreshnik Zejnullahu, Carly Murphy, Eugene Lifshits, Alison J. Holmes, Hwan Geun Choi, Jhingook Kim, Derek Chiang, Roman Thomas, Jinseon Lee, William G. Richards, David J. Sugarbaker, Christopher Ducko, Neal Lindeman, J. Paul Marcoux, Jeffrey A. Engelman, Nathanael S. Gray, Charles Lee, Matthew Meyerson, and Pasi A. Jänne
Clin Cancer Res 2008;14 4275-4283
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4275

Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma
Priya Koppikar, Seung-Ho Choi, Ann Marie Egloff, Quan Cai, Shinsuke Suzuki, Maria Freilino, Hiroshi Nozawa, Sufi M. Thomas, William E. Gooding, Jill M. Siegfried, and Jennifer R. Grandis
Clin Cancer Res 2008;14 4284-4291
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4284

Efficacy of Superoxide Dismutase Mimetic M40403 in Attenuating Radiation-Induced Oral Mucositis in Hamsters
Christopher K. Murphy, Edward G. Fey, Brynmor A. Watkins, Vivien Wong, David Rothstein, and Stephen T. Sonis
Clin Cancer Res 2008;14 4292-4297
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4292

Dendritic Cell Vaccination with Xenogenic Polypeptide Hormone Induces Tumor Rejection in Neuroendocrine Cancer
Claudia Papewalis, Margret Wuttke, Jochen Seissler, Yvonne Meyer, Caroline Kessler, Benedikt Jacobs, Evelyn Ullrich, Holger S. Willenberg, Sven Schinner, Thomas Baehring, Werner A. Scherbaum, and Matthias Schott
Clin Cancer Res 2008;14 4298-4305
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4298

Human CD4+ T Lymphocytes Recognize a Vascular Endothelial Growth Factor Receptor-2–Derived Epitope in Association with HLA-DR
Yuansheng Sun, Mingxia Song, Elke Jäger, Christina Schwer, Stefan Stevanovic, Sven Flindt, Julia Karbach, Xuan D. Nguyen, Dirk Schadendorf, and Klaus Cichutek
Clin Cancer Res 2008;14 4306-4315
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4306

Vaccination with a Recombinant Saccharomyces cerevisiae Expressing a Tumor Antigen Breaks Immune Tolerance and Elicits Therapeutic Antitumor Responses
Elizabeth K. Wansley, Mala Chakraborty, Kenneth W. Hance, Michael B. Bernstein, Amanda L. Boehm, Zhimin Guo, Deborah Quick, Alex Franzusoff, John W. Greiner, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2008;14 4316-4325
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4316

Synergistic Inhibition of ErbB Signaling by Combined Treatment with Seliciclib and ErbB-Targeting Agents
Ian N. Fleming, Morag Hogben, Sheelagh Frame, Steven J. McClue, and Simon R. Green
Clin Cancer Res 2008;14 4326-4335
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4326

Combined Inhibition of PLC-1 and c-Src Abrogates Epidermal Growth Factor Receptor–Mediated Head and Neck Squamous Cell Carcinoma Invasion
Hiroshi Nozawa, Gina Howell, Shinsuke Suzuki, Qing Zhang, Yanjun Qi, Judith Klein-Seetharaman, Alan Wells, Jennifer R. Grandis, and Sufi M. Thomas
Clin Cancer Res 2008;14 4336-4344
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4336

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Cancer Prevention and Susceptibility
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Functional Variants of the NEIL1 and NEIL2 Genes and Risk and Progression of Squamous Cell Carcinoma of the Oral Cavity and Oropharynx
Xiadong Zhai, Hui Zhao, Zhensheng Liu, Li-E Wang, Adel K. El-Naggar, Erich M. Sturgis, and Qingyi Wei
Clin Cancer Res 2008;14 4345-4352
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/13/4345

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Letters to the Editor
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Frontline Therapy for Chronic Lymphocytic Leukemia: The Dilemma Continues
Chadi Nabhan
Clin Cancer Res 2008;14 4353
http://clincancerres.aacrjournals.org/cgi/content/full/14/13/4353

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Corrections
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Correction: Article on Cyclooxygenase-2 and Platelet-derived Growth Factors as Targets in Treating Aggressive Fibromatosis
Clin Cancer Res 2008;14 4354
http://clincancerres.aacrjournals.org/cgi/content/full/14/13/4354

Correction: Article on CEACAM6 and Breast Cancer Recurrence
Clin Cancer Res 2008;14 4355-4356
http://clincancerres.aacrjournals.org/cgi/content/full/14/13/4355

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