Beyond A Cure

30 Jun 2008 | : *News*, Announcements

Web Bug from http://www.drsusanlove.com/newsletter/images/spacer.gif
June 2008

A Message from Dr. Love
Get Moving!
Now that weÂ’ve moved our offices to Santa Monica, IÂ’ve found a new way to add exercise to my day: biking to work from my home in Pacific Palisades. ItÂ’s about a 6-mile ride each way, itÂ’s far from flat, and it has at least three great benefits. It gets my heart rate up, which will help keep my heart healthy. IÂ’m getting vitamin D from the sun, which can help reduce my overall cancer risk. And IÂ’m burning calories, which will help me control my weight during menopause.

It feels great to be on my bike. It also feels great to talk about the fact that IÂ’m doing it! As you know, IÂ’m dedicated to ending breast cancer. But as we do the work that will get us there, I also am doing my best to promote a lifestyle that will help women reduce their risk of getting this disease. (See, I really do practice what I preach!)

ThereÂ’s also another important reason to try to squeeze this type of exercise into your day: The mounting evidence that regular exercise not only can help prevent breast cancer but also can help reduce the risk of a cancer recurrence.
MORE>
Hot Topics
ASCO 2008: Three Important Breast Cancer Studies
The American Society of Clinical Oncology (ASCO) held its annual meeting May 30 – June 3 in Chicago. At this year’s conference, there were three breast cancer related studies that drew extensive media attention:

* Zoledronic Acid (Zometa) Reduces Recurrence Researchers presented data from a study that found that giving zoledronic acid (Zometa), a bone building drug, to premenopausal women undergoing ovarian suppression and hormone therapy significantly reduced the risk of recurrence in early-stage breast cancer.

Researchers presented data from a study that found that adding bevacizumab (Avastin) to docetaxel (Taxotere) slows disease progression in women newly diagnosed with locally advanced or metastatic breast cancer. This study adds to previous findings on bevacizumab for treating breast cancer.

Researchers presented data from a study that found that standard chemotherapy was more effective than the oral chemotherapy drug capecitabine (Xeloda) in older women with early stage breast cancer.

Learn what you need to know about these three studies here.
Cause for Love
Over $50,000 Raised at First Annual Love Walk
 hspace= The Foundation sends a special “thank you” to the Pacific Palisades Junior Women’s Club, City National Bank, Prudential California Realty, The Pump Station and the more than 400 people who joined Dr. Love on May 18th for the First Annual Love Walk. The walk raised more than $50,000 for the Foundation’s research program. Stay tuned for more information about Love Walk 2009!
*Photo by Rich Schmitt

Make Dr. Love’s 60th Birthday the “Year of Love”
In celebration of Dr. Love’s 60th birthday, and in recognition of her pioneering work as a breast cancer surgeon, advocate, and researcher, the Foundation invites you to join us in the Year of Love. Our goal is to raise $600,000 in honor of Dr. Love and her work. With your help, we can do it! When you donate in Dr. Love’s honor, you’ll have the opportunity to send her a personal message, which will be included on her virtual birthday card on our website. Donations in honor of Dr. Love can be made throughout 2008. Make a donation and send your birthday wishes.
Research Update
Women Needed for Groundbreaking DCIS Study
The Foundation is looking for 30 Northern Californian women who have recently been diagnosed with ductal carcinoma in situ (DCIS) to take part in a groundbreaking new research project that involves injecting a small amount of a chemotherapy drug into the affected breast duct. Study participants will then have their DCIS surgery four to six weeks later. The breast tissue collected during the surgery will be carefully examined to see the effects of the drug on the DCIS. If the study successfully shows that the drug has an impact on the DCIS, it could lead to a nationwide clinical trial of intraductal therapy for DCIS.

This research project, which was funded by the California Breast Cancer Research Program, is being conducted in collaboration with Ellen Mahoney, MD, and the Humboldt Community Breast Heath Project. Research participants will need to travel to Eureka, Calif., for the treatment and the surgery. Please call Ashley Casano at (310) 230-1712 Ext. 32 or send her an email for more information.
© 2006-2008 Dr. Susan Love Research Foundation
All rights reserved
Did You Know?
Cancer occurs when a normal cell stops functioning properly and begins to grow and divide uncontrollably. This process doesn’t occur in a day, or in a month, or even in a year. It typically takes decades or more for a normal cell to transform into a cancer cell. MORE >
Your Questions
Do you have any suggestions for controlling weight gain during menopause and/or perimenopause?
Weight maintenance and weight gain are both critical issues for many women during the perimenopause and menopause years. The first place to begin is by looking at and assessing your overall diet and lifestyle.
MORE >
Stories of Courage
Is Your Personal Story on Our Website?
Over the past five years, weÂ’ve had nearly 100 women and men submit their Personal Stories to our website. If you are one of them, we hope youÂ’ll consider sending us an update that we can add to your story. Email your update to us at editor@dslrf.org.

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Leukemia & Lymphoma Society

23 Jun 2008 | : *News*


The Leukemia & Lymphoma Society
888.HELP.LLS Donate Now Forward to a Friend

Dave and Jennifer House In our last message, we told you the story of a member of the LLS family who found comfort and support from our First Connection Program.  The response was enormously positive, so, continuing in that vein, this email tells another LLS family story.  My hope is that hearing real stories of the people who benefit from your support will reinforce the importance of your contributions and strengthen your own bond to the LLS family. You are free to unsubscribe from this series of emails at any time, but I hope instead you will read them and find the material informative and uplifting.

Dave House is a blood cancer patient who became part of the LLS family while searching for information after his diagnosis.  He also discovered something else of value:  LLS’s Co-Pay Assistance Program.  To learn more about this program, please visit our site.

First they thought it was Lyme disease. But the antibiotics didn’t seem to work.  When Dave House went in for follow-up treatment, a mass in his neck was discovered.  One surgery and a biopsy later, during Thanksgiving week, they learned the truth-and it was devastating.  Dave had Hodgkin lymphoma.  Neither Dave nor his wife, Jennifer, knew much about this cancer, but immediately, both wanted to find out all they could.

An Internet search led them to www.LLS.org.  “Finally, a source for reliable, recent and understandable information for all of us,” explains Dave. “The site was quickly ‘bookmarked’ and is referred to on an almost daily basis. It helps us to understand what we are dealing with and prepares us for what’s coming.”

One thing that came all too quickly was the unexpected financial repercussions of cancer treatment, which were particularly alarming.  The House’s were not accustomed to needing help, and learning to accept assistance was difficult.  But when your life is at stake, you do what you have to do.  The family learned that LLS has a Co-Pay Assistance Program to help eligible blood cancer patients and their families cope with the costs of healthcare insurance premiums and co-pays. Dave applied for financial support through the program and was accepted.  “Without it,” he says, “we couldn’t have afforded the medications I need to get well.”

Dave is still in treatment and managing to stay in good spirits.  “Your life will change,” he says.  “How and how much depends on you.”  But he advises others in his situation to try and be open to accepting help from others and to maintain a sense of humor, adding, “It works wonders.”

If you have a story to share, please contact us.  To learn more about LLS, please visit us at www.lls.org .

Best of health,
John E. Walter
John E. Walter
President & CEO
The Leukemia & Lymphoma Society (LLS) is the world’s largest voluntary health organization dedicated to funding blood cancer research, education and patient services. LLS’s mission: Cure leukemia, lymphoma, Hodgkin’s disease and myeloma, and improve the quality of life of patients and their families. See how your donations are invested wisely.

Home Office
1311 Mamaroneck Avenue • White Plains, NY 10605
914.949.5213 • www.LLS.org

© 2008 The Leukemia & Lymphoma Society
All Rights Reserved

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16 Jun 2008 | : *News*, Announcements

June 2008

The new issue of CancerWise is now available online at www.cancerwise.org

  • Tonsil Cancer Patient Has Full Recovery
    Tonsil cancer survivor Earle Wright talks about his journey from cancer diagnosis and treatment to recovery.
    Read More
  • Q&A: What to Know About Tonsil Cancer
    Whether people have had their tonsils removed or not, they still might develop tonsil cancer and should be educated about the disease. Answering questions about tonsil cancer is Ann Gillenwater, M. D., associate professor in M. D. Anderson’s Department of Head and Neck Surgery and director of the cancer center’s Oral Cancer Prevention Clinic.
    Read More
  • Cancer Pain Treatment Is Complex
    Cancer pain is seldom simple and often requires a variety of methods to treat layers of physical and mental causes and aggravating factors, says Allen Burton, M.D., professor and clinical medical director of M. D. Anderson’s Pain Management Center.
    Read More
CancerWise Articles
Forward to a Friend Feedback
If you think this publication would be helpful to friends or loved ones, pass on this e-mail. If they are interested in subscribing, they can click on the following link: Subscribe to CancerWise We are very interested in hearing your thoughts about CancerWise. Please use our feedback form to tell us what you think.
To learn moreabout The University of Texas M. D. Anderson Cancer Center, visit our website. If you have questions about the content in CancerWise or need assistance with this subscription, simply reply to this message.
(c)2007 The University of Texas M. D. Anderson Cancer Center
The material and content contained in CancerWise is for general health information only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Users of CancerWise should not rely exclusively on information provided in CancerWise for their own health needs. All specific medical questions should be presented to your own health care provider.

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LGBT Cancer Network

16 Jun 2008 | : Announcements

June 13, 2008 Brought to you by Organization

Become a Network “hub”

Picture a map of the country with colored pushpins representing the locations of active Network members.  Imagine the lines that connect each of these “hubs” with all the others.  With nearly 1,000 oncologists, social workers, survivors, researchers and health activists on our mailing list in just 8 months of operation, we have the potential to create such a network of collaboration today.   Already, we have active members in New York City, Omaha, Los Angeles, Chicago, Austin, Boston and Kalamazoo.

Please consider creating or becoming a “hub” where you live or work, serving as the local resource for the Network.   Help us connect to the providers and LGBT cancer survivors in your part of the country.  Become a local expert on cancer in the LGBT community.  When requests come in for presentations in your area,  help us organize our trip or give the presentation yourself, using our curriculum and support.

To become a local “hub” of the National LGBT Cancer Network, contact Liz Margolies, LCSW, Executive Director, for more information.

It is a great way to get more involved in the Network and connect with others who also want to make a difference in the lives of LGBT people with cancer and those at risk.  Check out our website for more information about the education, advocacy and training work of the Network.

Board of Directors

On June 9th, the National LGBT Cancer Network held its very first meeting of the Board of Directors, electing the officers who will help guide the organization.

Please welcome Maxine Blake (President), Nancy Wackstein (Vice President), Cassie DuPrey (Secretary), Lois Rice (Treasurer), Andy Miller, Michael Pierce and Becky Allegretto.

We have space for one more Director.  Please contact us if you are interested in participating .

Recent Presentations

In the last few months, the National LGBT Cancer Network has been quite active, giving presentations around the country.  In the last month alone, we have presented at

  • The Wellness Community (Pasadena, CA)
  • The Maine LGBTI Health Summit (Augusta ME)
  • LGBT Senior Health Fair (New York, NY)
  • Healthy People 2020 regional meeting (New York, NY)
  • SHARE (Syracuse, NY)
  • Sexual and Gender Minorities Workgroup of the Center for Disease Control (Atlanta, GE)

To learn more or to schedule a presentation in your area, contact us or check out our website.

Become a hub

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Dana-Farber e-News

10 Jun 2008 | : *News*

This Month
June Spotlight:
Survivorship
Learn more about the issues facing cancer survivors, view videos of survivors and survivorship care providers, read related stories and patient profiles, and ask our survivorship experts a question. Explore Spotlight
Monthly health quiz
What is the probability of a male developing invasive cancer during his lifetime?
Take the quiz
Nutrition tip and recipe of the month
High consumption of fruits and vegetables have shown a significant protective effect against developing cancer. Incorporate a variety of vegetables into your diet with this Veggie Pizza.
Get the recipe
Ask the Nutritionist
Online Stores
Show your pride for Dana-Farber by sporting an item from our online stores. Choose from dozens of products with the Dana-Farber, Jimmy Fund, or individual event logo.
Browse online stores
How to Help
A Premiere Cause: Get Smart
Join Steve Carell for a special screening of his new film “Get Smart” to benefit the Zachary Carson Brain Tumor Fund at Dana-Farber. Learn more
Dana-Farber e-cards
Send an e-card for any occasion. With a minimum $5 gift, honor a friend and brighten someone’s day while supporting Dana-Farber’s lifesaving mission.
View e-cards
Mission Possible Campaign
For 60 years, it has been our vision to eradicate cancer and the fear it engenders. Support Dana-Farber’s $1 billion campaign to conquer cancer. Mission Possible Campaign
Make a gift
Your gift to Dana-Farber helps us find cures for cancer and related diseases and makes a difference in the lives of those living with cancer. Make a gift
Resources
Feedback
We are very interested in your thoughts about our newsletter. Please send us an e-mail.
For more information about our programs and services, visit www.dana-farber.org or www.jimmyfund.org.
Dedicated to Discovery. Committed to Care.
Featured Story
JUNE 2008
Breast cancer cells
Study suggests chemotherapy diminishes fertility in breast cancer patients
Pre-menopausal breast cancer survivors who were treated with chemotherapy following surgery were more likely to have diminished ovarian reserve - the capacity of the ovaries to provide eggs capable of being fertilized - compared to women who have never had breast cancer, according to a study led by Dana-Farber investigators. Read more
News
Comfort Room

Black patients with terminal cancer more likely to choose aggressive care at end of life, study shows

Black patients with advanced cancer were more likely than whites to die in a hospital intensive care unit, reflecting a greater preference among blacks for life-extending treatment even in the face of a terminal prognosis, according to a study led by researchers at Dana-Farber. Read more
test tubes

Smokers with advanced colon cancer may face higher odds of disease recurrence

People with advanced colon cancer who have smoked cigarettes or used other tobacco products for many years may have an increased risk that their colon cancer will return, according to research by Dana-Farber scientists. Read more
Breast cancer cell

Black and Hispanic women less likely than white women to receive follow-up radiation for early breast cancer, study shows

Black and Hispanic women are less likely than white women to receive the radiation therapy routinely prescribed following surgery for early breast cancer, according to a study by Dana-Farber researchers. Read more
Jennifer Chan, MD, MPH

Family history predicts better outcome in colorectal cancer

Researchers at Dana-Farber have uncovered a cancer paradox: A family history of colon or rectal cancer doubles one’s risk of the disease - but improves the odds of survival should the cancer develop. Read more
Caroline Bridges

Survivor Story: Caroline Bridges learns a “new normal”

For Caroline Bridges, the hardest part about being diagnosed with leukemia during her sophomore year at Boston University was giving up her “normal” life. Read her story
David Pellman, MD

Pediatric oncologist selected as Howard Hughes Medical Institute investigator

David Pellman, MD, a pediatric oncologist at Dana-Farber and Children’s Hospital Boston, is one of 56 scientists just selected as an investigator of the Howard Hughes Medical Institute (HHMI), a non-profit medical research organization that ranks as one of the nation’s largest philanthropies.
Read more
Save the Date
Dana-Farber Cancer Institute
Wednesday, June 11, 2008
Living with Gynecologic Cancer
Smith 764
6-7:30 p.m.
This seminar is for patients currently diagnosed with gynecologic cancer. To register, call Sarah Reed, LCSW, at (617) 632-3304.
Jimmy Fund collection canister
June 13 - August 3, 2008
Jimmy Fund/Variety Children’s Charity Theatre Program
The Theatre Collections Program is the Jimmy Fund’s oldest annual fundraising effort. Volunteer at your local theatre or give generously when the Jimmy Fund canister comes your way.
Volunteer now | View movie trailers
Living Proof logo
June 16-20, 2008
National Cancer Survivors’ Week
Living Proof: Celebrating Survivorship Workshops
Dana-Farber and the Perini Family Survivors’ Center will recognize National Cancer Survivors’ Week during the third week of June. The event features more than a dozen workshops on topics such as health insurance, finances, complementary therapies, nutrition, spirituality and advocacy. For more information or to register, please call (800) 883-6012.
Learn more and view workshop descriptions
Jimmy Fund Golf logo
Through October 2008
Jimmy Fund Golf
Now in its 26th year, Jimmy Fund Golf is one of the largest organized golf programs in the U.S. Host a tournament and raise critical funds for cancer research while enjoying your favorite pastime. Learn more

For more information

To view all of our upcoming seminars, workshops, and fundraising events, go to our Event Calendar. Learn more
© Dana-Farber Cancer Institute | 44 Binney Street | Boston, MA 02115 | www.dana-farber.org

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Clinical Cancer Research

03 Jun 2008 | : *News*

A new issue of Clinical Cancer Research is available online:
1 June 2008; Vol. 14, No. 11

The below Table of Contents is available online at: http://clincancerres.aacrjournals.org/content/vol14/issue11/?etoc

——————————————————————————–
Molecular Pathways
——————————————————————————–

Neuregulins and Cancer
Juan Carlos Montero, Ruth Rodríguez-Barrueco, Alberto Ocaña, Elena Díaz-Rodríguez, Azucena Esparís-Ogando, and Atanasio Pandiella
Clin Cancer Res 2008;14 3237-3241
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3237

——————————————————————————–
Report from the FDA
——————————————————————————–

Continuing Reassessment of the Risks of Erythropoiesis-Stimulating Agents in Patients with Cancer
Vinni Juneja, Patricia Keegan, Joseph E. Gootenberg, Mark D. Rothmann, Yuan Li Shen, Kyung Y. Lee, Karen D. Weiss, and Richard Pazdur
Clin Cancer Res 2008;14 3242-3247
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3242

——————————————————————————–
Human Cancer Biology
——————————————————————————–

Impact of a Single Nucleotide Polymorphism in the MDM2 Gene on Neuroblastoma Development and Aggressiveness: Results of a Pilot Study on 239 Patients
Sara Cattelani, Raffaella Defferrari, Sonia Marsilio, Rita Bussolari, Olivia Candini, Francesca Corradini, Giovanna Ferrari-Amorotti, Clara Guerzoni, Luisa Pecorari, Chiara Menin, Roberta Bertorelle, Pierluigi Altavista, Heather P. McDowell, Renata Boldrini, Carlo Dominici, Gian Paolo Tonini, Giuseppe Raschellà, and Bruno Calabretta
Clin Cancer Res 2008;14 3248-3253
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3248

Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing
Karen Sandell Sfanos, Tullia C. Bruno, Charles H. Maris, Lauren Xu, Christopher J. Thoburn, Angelo M. DeMarzo, Alan K. Meeker, William B. Isaacs, and Charles G. Drake
Clin Cancer Res 2008;14 3254-3261
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3254

Involvement of Hepcidin in the Anemia of Multiple Myeloma
Sanjai Sharma, Elizabeta Nemeth, Yi-Hsiang Chen, Julia Goodnough, Alissa Huston, G.D. Roodman, Tomas Ganz, and Alan Lichtenstein
Clin Cancer Res 2008;14 3262-3267
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3262

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models
Alex R. Shoemaker, Michael J. Mitten, Jessica Adickes, Scott Ackler, Marion Refici, Debra Ferguson, Anatol Oleksijew, Jacqueline M. O’Connor, Baole Wang, David J. Frost, Joy Bauch, Kennan Marsh, Steven K. Tahir, Xiufen Yang, Christin Tse, Stephen W. Fesik, Saul H. Rosenberg, and Steven W. Elmore
Clin Cancer Res 2008;14 3268-3277
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3268

Mutant Epidermal Growth Factor Receptor in Benign, Borderline, and Malignant Ovarian Tumors
Karina Dahl Steffensen, Marianne Waldstrøm, Dorte Aalund Olsen, Thomas Corydon, Karen Axelgaard Lorentzen, Hans Jørgen Knudsen, Ulla Jeppesen, Ivan Brandslund, and Anders Jakobsen
Clin Cancer Res 2008;14 3278-3282
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3278

Intertumor and Intratumor NY-ESO-1 Expression Heterogeneity Is Associated with Promoter-Specific and Global DNA Methylation Status in Ovarian Cancer
Anna Woloszynska-Read, Paulette Mhawech-Fauceglia, Jihnhee Yu, Kunle Odunsi, and Adam R. Karpf
Clin Cancer Res 2008;14 3283-3290
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3283

ECSA/DPPA2 is an Embryo-Cancer Antigen that Is Coexpressed with Cancer-Testis Antigens in Non–Small Cell Lung Cancer
Thomas John, Otavia L. Caballero, Suzanne J. Svobodová, Alan Kong, Ramon Chua, Judy Browning, Sheila Fortunato, Siddhartha Deb, Melinda Hsu, Craig A. Gedye, Ian D. Davis, Nasser Altorki, Andrew J. Simpson, Yao-Tseng Chen, Marilyn Monk, and Jonathan S. Cebon
Clin Cancer Res 2008;14 3291-3298
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3291

Focal Adhesion Kinase Expression in Human Neuroblastoma: Immunohistochemical and Real-time PCR Analyses
Elizabeth A. Beierle, Nicole A. Massoll, Joseph Hartwich, Elena V. Kurenova, Vita M. Golubovskaya, William G. Cance, Patrick McGrady, and Wendy B. London
Clin Cancer Res 2008;14 3299-3305
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3299

——————————————————————————–
Imaging, Diagnosis, Prognosis
——————————————————————————–

Disseminated Tumor Cells of Breast Cancer Patients: A Strong Prognostic Factor for Distant and Local Relapse
Francois-Clément Bidard, Anne Vincent-Salomon, Stéphanie Gomme, Claude Nos, Yann de Rycke, Jean Paul Thiery, Brigitte Sigal-Zafrani, Laurent Mignot, Xavier Sastre-Garau, Jean-Yves Pierga for the Institut Curie Breast Cancer Study Group
Clin Cancer Res 2008;14 3306-3311
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3306

Effect of SLCO1B3 Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic Cancer
Akinobu Hamada, Tristan Sissung, Douglas K. Price, Romano Danesi, Cindy H. Chau, Nima Sharifi, David Venzon, Kenji Maeda, Keisuke Nagao, Alex Sparreboom, Hiroaki Mitsuya, William L. Dahut, and William D. Figg
Clin Cancer Res 2008;14 3312-3318
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3312

Astrocyte Elevated Gene-1 is a Novel Prognostic Marker for Breast Cancer Progression and Overall Patient Survival
Jun Li, Nu Zhang, Li-Bing Song, Wen-Ting Liao, Li-Li Jiang, Li-Yun Gong, Jueheng Wu, Jie Yuan, Hui-Zhong Zhang, Mu-Sheng Zeng, and Mengfeng Li
Clin Cancer Res 2008;14 3319-3326
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3319

Identification of Genes Differentially Expressed in Benign versus Malignant Thyroid Tumors
Nijaguna B. Prasad, Helina Somervell, Ralph P. Tufano, Alan P.B. Dackiw, Michael R. Marohn, Joseph A. Califano, Yongchun Wang, William H. Westra, Douglas P. Clark, Christopher B. Umbricht, Steven K. Libutti, and Martha A. Zeiger
Clin Cancer Res 2008;14 3327-3337
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3327

AP1-Dependent Galectin-1 Expression Delineates Classical Hodgkin and Anaplastic Large Cell Lymphomas from Other Lymphoid Malignancies with Shared Molecular Features
Scott J. Rodig, Jing Ouyang, Przemyslaw Juszczynski, Treeve Currie, Kenneth Law, Donna S. Neuberg, Gabriel A. Rabinovich, Margaret A. Shipp, and Jeffery L. Kutok
Clin Cancer Res 2008;14 3338-3344
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3338

Prediction of Nodal Involvement in Breast Cancer Based on Multiparametric Protein Analyses from Preoperative Core Needle Biopsies of the Primary Lesion
Georg Sauer, Nicole Schneiderhan-Marra, Cornelia Kazmaier, Kathrin Hutzel, Karin Koretz, Rainer Muche, Rolf Kreienberg, Thomas Joos, and Helmut Deissler
Clin Cancer Res 2008;14 3345-3353
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3345

Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of CDH13 Hypermethylation
Yutaka Suehiro, Toshiyuki Okada, Takae Okada, Keiko Anno, Naoko Okayama, Koji Ueno, Mikako Hiura, Mikiko Nakamura, Tomoko Kondo, Atsunori Oga, Shigeto Kawauchi, Kei Hirabayashi, Fumitaka Numa, Takehisa Ito, Toshiaki Saito, Kohsuke Sasaki, and Yuji Hinoda
Clin Cancer Res 2008;14 3354-3361
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3354

Preoperative Plasma Endoglin Levels Predict Biochemical Progression After Radical Prostatectomy
Robert S. Svatek, Jose A. Karam, Claus G. Roehrborn, Pierre I. Karakiewicz, Kevin M. Slawin, and Shahrokh F. Shariat
Clin Cancer Res 2008;14 3362-3366
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3362

Genetic Polymorphism in EGF Is Associated with Prostate Cancer Aggressiveness and Progression-Free Interval in Androgen Blockade–Treated Patients
Ana L. Teixeira, Ricardo Ribeiro, Diana Cardoso, Daniela Pinto, Francisco Lobo, Avelino Fraga, Francisco Pina, Fernando Calais-da-Silva, and Rui Medeiros
Clin Cancer Res 2008;14 3367-3371
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3367

HLA Class I Antigen Processing Machinery Component Expression and Intratumoral T-Cell Infiltrate as Independent Prognostic Markers in Ovarian Carcinoma
Liz Y. Han, Mavis S. Fletcher, Diana L. Urbauer, Peter Mueller, Charles N. Landen, Aparna A. Kamat, Yvonne G. Lin, William M. Merritt, Whitney A. Spannuth, Michael T. Deavers, Koen De Geest, David M. Gershenson, Susan K. Lutgendorf, Soldano Ferrone, and Anil K. Sood
Clin Cancer Res 2008;14 3372-3379
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3372

Characterization of TMPRSS2-ERG Fusion High-Grade Prostatic Intraepithelial Neoplasia and Potential Clinical Implications
Juan-Miguel Mosquera, Sven Perner, Elizabeth M. Genega, Martin Sanda, Matthias D. Hofer, Kirsten D. Mertz, Pamela L. Paris, Jeff Simko, Tarek A. Bismar, Gustavo Ayala, Rajal B. Shah, Massimo Loda, and Mark A. Rubin
Clin Cancer Res 2008;14 3380-3385
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3380

Protein Expression of Platelet-Derived Growth Factor Receptor Correlates with Malignant Histology and PTEN with Survival in Childhood Gliomas
Halldora K. Thorarinsdottir, Mariarita Santi, Robert McCarter, Elisabeth J. Rushing, Robert Cornelison, Alessandra Jales, and Tobey J. MacDonald
Clin Cancer Res 2008;14 3386-3394
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3386

TMPRSS2:ERG Fusion Identifies a Subgroup of Prostate Cancers with a Favorable Prognosis
Outi R. Saramäki, Anna E. Harjula, Paula M. Martikainen, Robert L. Vessella, Teuvo L.J. Tammela, and Tapio Visakorpi
Clin Cancer Res 2008;14 3395-3400
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3395

Human High Molecular Weight–Melanoma-Associated Antigen: Utility for Detection of Metastatic Melanoma in Sentinel Lymph Nodes
Yasufumi Goto, Soldano Ferrone, Takaaki Arigami, Minoru Kitago, Atsushi Tanemura, Eiji Sunami, Sandy L. Nguyen, Roderick R. Turner, Donald L. Morton, and Dave S.B. Hoon
Clin Cancer Res 2008;14 3401-3407
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3401

Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer
Amy J. French, Daniel J. Sargent, Lawrence J. Burgart, Nathan R. Foster, Brian F. Kabat, Richard Goldberg, Lois Shepherd, Harold E. Windschitl, and Stephen N. Thibodeau
Clin Cancer Res 2008;14 3408-3415
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3408

Changes in Tumor Metabolism as Readout for Mammalian Target of Rapamycin Kinase Inhibition by Rapamycin in Glioblastoma
Liu Hua Wei, Helen Su, Isabel J. Hildebrandt, Michael E. Phelps, Johannes Czernin, and Wolfgang A. Weber
Clin Cancer Res 2008;14 3416-3426
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3416

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Cancer Therapy: Clinical
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Development of Clinical Trials in a Cooperative Group Setting: The Eastern Cooperative Oncology Group
David M. Dilts, Alan Sandler, Steven Cheng, Joshua Crites, Lori Ferranti, Amy Wu, Robert Gray, Jean MacDonald, Donna Marinucci, and Robert Comis
Clin Cancer Res 2008;14 3427-3433
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3427

A Phase I and Pharmacokinetic Study of Weekly Oxaliplatin Followed by Paclitaxel in Patients with Solid Tumors
Tanios S. Bekaii-Saab, Jing Liu, Kenneth K. Chan, Stanley P. Balcerzak, Percy S. Ivy, Michael R. Grever, and Eric H. Kraut
Clin Cancer Res 2008;14 3434-3440
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3434

Evaluation of the Pharmacodynamic Effects of MGCD0103 from Preclinical Models to Human Using a Novel HDAC Enzyme Assay
Claire Bonfils, Ann Kalita, Marja Dubay, Lillian L. Siu, Michael A. Carducci, Gregory Reid, Robert E. Martell, Jeffrey M. Besterman, and Zuomei Li
Clin Cancer Res 2008;14 3441-3449
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3441

A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies
Sébastien J. Hotte, Hal W. Hirte, Eric X. Chen, Lillian L. Siu, Lyly H. Le, Alfred Corey, Anne Iacobucci, Martha MacLean, Larry Lo, Norma Lynn Fox, and Amit M. Oza
Clin Cancer Res 2008;14 3450-3455
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3450

A Phase I Study of 17-Allylamino-17-Demethoxygeldanamycin Combined with Paclitaxel in Patients with Advanced Solid Malignancies
Suresh S. Ramalingam, Merrill J. Egorin, Ramesh K. Ramanathan, Scot C. Remick, Rachel P. Sikorski, Theodore F. Lagattuta, Gurkamal S. Chatta, David M. Friedland, Ronald G. Stoller, Douglas M. Potter, S. Percy Ivy, and Chandra P. Belani
Clin Cancer Res 2008;14 3456-3461
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3456

A Dose-Escalation Study of Recombinant Human Interleukin-18 Using Two Different Schedules of Administration in Patients with Cancer
Michael J. Robertson, John M. Kirkwood, Theodore F. Logan, Kevin M. Koch, Steven Kathman, Lyndon C. Kirby, William N. Bell, Linda M. Thurmond, Jill Weisenbach, and Mohammed M. Dar
Clin Cancer Res 2008;14 3462-3469
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3462

Hypertension and Rarefaction during Treatment with Telatinib, a Small Molecule Angiogenesis Inhibitor
Neeltje Steeghs, Hans Gelderblom, Jos op ‘t Roodt, Olaf Christensen, Prabhu Rajagopalan, Marcel Hovens, Hein Putter, Ton J. Rabelink, and Eelco de Koning
Clin Cancer Res 2008;14 3470-3476
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3470

Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study
Stephan A. Veltkamp, Robert S. Jansen, Sophie Callies, Dick Pluim, Carla M. Visseren-Grul, Hilde Rosing, Susanne Kloeker-Rhoades, Valerie A.M. Andre, Jos H. Beijnen, Christopher A. Slapak, and Jan H.M. Schellens
Clin Cancer Res 2008;14 3477-3486
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3477

Adjuvant Radioimmunotherapy Trial with Iodine-131–Labeled Anti–Carcinoembryonic Antigen Monoclonal Antibody F6 F(ab’)2 after Resection of Liver Metastases from Colorectal Cancer
Marc Ychou, David Azria, Cathy Menkarios, Patrick Faurous, François Quenet, Bernard Saint-Aubert, Philippe Rouanet, Monique Pèlegrin, Caroline Bascoul-Mollevi, Dominique Guerreau, Jean-Claude Saccavini, Jean-Pierre Mach, Jean-Claude Artus, and André Pèlegrin
Clin Cancer Res 2008;14 3487-3493
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3487

Methylated NEUROD1 Promoter is a Marker for Chemosensitivity in Breast Cancer
Heidi Fiegl, Allison Jones, Cornelia Hauser-Kronberger, Georg Hutarew, Roland Reitsamer, Robin L. Jones, Mitch Dowsett, Elisabeth Mueller-Holzner, Gudrun Windbichler, Günter Daxenbichler, Georg Goebel, Christian Ensinger, Ian Jacobs, and Martin Widschwendter
Clin Cancer Res 2008;14 3494-3502
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3494

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Cancer Therapy: Preclinical
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Proteasome β Subunit Pharmacogenomics: Gene Resequencing and Functional Genomics
Liewei Wang, Shaji Kumar, Brooke L. Fridley, Krishna R. Kalari, Irene Moon, Linda L. Pelleymounter, Michelle A.T. Hildebrandt, Anthony Batzler, Bruce W. Eckloff, Eric D. Wieben, and Philip R. Greipp
Clin Cancer Res 2008;14 3503-3513
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3503

Retinoblastoma RB94 Enhances Radiation Treatment of Head and Neck Squamous Cell Carcinoma
Koji Araki, Sidrah M. Ahmad, Guoyan Li, David A. Bray, Jr, Koichiro Saito, Daiyou Wang, Uwe Wirtz, Sunil Sreedharan, Bert W. O’Malley, Jr, and Daqing Li
Clin Cancer Res 2008;14 3514-3519
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3514

Direct and Natural Killer Cell-Mediated Antitumor Effects of Low-Dose Bortezomib in Hepatocellular Carcinoma
Sorin Armeanu, Matthias Krusch, Katrin M. Baltz, Thomas S. Weiss, Irina Smirnow, Alexander Steinle, Ulrich M. Lauer, Michael Bitzer, and Helmut R. Salih
Clin Cancer Res 2008;14 3520-3528
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3520

Modulation of Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-Tetrahydrouridine
Jan H. Beumer, Julie L. Eiseman, Robert A. Parise, Erin Joseph, Joseph M. Covey, and Merrill J. Egorin
Clin Cancer Res 2008;14 3529-3535
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3529

Combination of Docetaxel and Recombinant Vaccine Enhances T-Cell Responses and Antitumor Activity: Effects of Docetaxel on Immune Enhancement
Charlie T. Garnett, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2008;14 3536-3544
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3536

Lymphocyte Activation Gene-3 Fusion Protein Increases the Potency of a Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Cell Immunotherapy
Betty Li, Melinda VanRoey, Frederic Triebel, and Karin Jooss
Clin Cancer Res 2008;14 3545-3554
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3545

Preclinical Evaluation of the -Particle Generator Nuclide 225Ac for Somatostatin Receptor Radiotherapy of Neuroendocrine Tumors
Matthias Miederer, Gjermund Henriksen, Andrea Alke, Ilona Mossbrugger, Leticia Quintanilla-Martinez, Reingard Senekowitsch-Schmidtke, and Markus Essler
Clin Cancer Res 2008;14 3555-3561
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3555

The Iroquois Homeobox Gene 5 Is Regulated by 1,25-Dihydroxyvitamin D3 in Human Prostate Cancer and Regulates Apoptosis and the Cell Cycle in LNCaP Prostate Cancer Cells
Anne Myrthue, Brooks L.S. Rademacher, Janet Pittsenbarger, Bozena Kutyba-Brooks, Marin Gantner, David Z. Qian, and Tomasz M. Beer
Clin Cancer Res 2008;14 3562-3570
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3562

Combining Nanoliposomal Ceramide with Sorafenib Synergistically Inhibits Melanoma and Breast Cancer Cell Survival to Decrease Tumor Development
Melissa A. Tran, Charles D. Smith, Mark Kester, and Gavin P. Robertson
Clin Cancer Res 2008;14 3571-3581
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3571

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer
Yuko Tsuruta, Larisa Pereboeva, Martina Breidenbach, Daniel T. Rein, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Paul Dent, Paul B. Fisher, and David T. Curiel
Clin Cancer Res 2008;14 3582-3588
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3582

Combination Strategy Targeting the Hypoxia Inducible Factor-1 with Mammalian Target of Rapamycin and Histone Deacetylase Inhibitors
Henk M.W. Verheul, Brenda Salumbides, Karen Van Erp, Hans Hammers, David Z. Qian, Tolib Sanni, Peter Atadja, and Roberto Pili
Clin Cancer Res 2008;14 3589-3597
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3589

A Paclitaxel-Hyaluronan Bioconjugate Targeting Ovarian Cancer Affords a Potent In vivo Therapeutic Activity
Alessandra Banzato, Sara Bobisse, Maria Rondina, Davide Renier, Fabio Bettella, Giovanni Esposito, Luigi Quintieri, Laura Meléndez-Alafort, Ulderico Mazzi, Paola Zanovello, and Antonio Rosato
Clin Cancer Res 2008;14 3598-3606
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3598

Nonviral Nanoscale-Based Delivery of Antisense Oligonucleotides Targeted to Hypoxia-Inducible Factor 1 Enhances the Efficacy of Chemotherapy in Drug-Resistant Tumor
Yang Wang, Maha Saad, Refika I. Pakunlu, Jayant J. Khandare, Olga B. Garbuzenko, Alexandre A. Vetcher, Viatcheslav A. Soldatenkov, Vitaly P. Pozharov, and Tamara Minko
Clin Cancer Res 2008;14 3607-3616
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3607

Matrix metalloproteinase-9 Inhibition Down-Regulates Radiation-Induced Nuclear Factor-B Activity Leading to Apoptosis in Breast Tumors
Sateesh Kunigal, Sajani S. Lakka, Pushpa Joseph, Norman Estes, and Jasti S. Rao
Clin Cancer Res 2008;14 3617-3626
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3617

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Cancer Prevention and Susceptibility
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Gly82Ser Polymorphism of the Receptor for Advanced Glycation End Products Is Associated with an Increased Risk of Gastric Cancer in a Chinese Population
Haijuan Gu, Li Yang, Qingmin Sun, Bo Zhou, Naping Tang, Rihong Cong, Ying Zeng, and Bin Wang
Clin Cancer Res 2008;14 3627-3632
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3627

A Novel Functional Polymorphism C1797G in the MDM2 Promoter Is Associated with Risk of Bladder Cancer in a Chinese Population
Meilin Wang, Zhizhong Zhang, Haixia Zhu, Guangbo Fu, Shouyu Wang, Dongmei Wu, Jianwei Zhou, Qingyi Wei, and Zhengdong Zhang
Clin Cancer Res 2008;14 3633-3640
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/11/3633

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Corrections
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Corrrection: Article on Cardiac Toxicity and Trastuzumab Combined with Pertuzumab
Clin Cancer Res 2008;14 3641
http://clincancerres.aacrjournals.org/cgi/content/full/14/11/3641

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