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The below Table of Contents is available online at: http://clincancerres.aacrjournals.org/content/vol14/issue10/?etoc

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Molecular Pathways
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Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer
Jeffrey A. Engelman and Pasi A. Jänne
Clin Cancer Res 2008;14 2895-2899
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2895

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Review
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Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma
Jann N. Sarkaria, Gaspar J. Kitange, C. David James, Ruth Plummer, Hilary Calvert, Michael Weller, and Wolfgang Wick
Clin Cancer Res 2008;14 2900-2908
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2900

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Human Cancer Biology
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Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells
Kentaro Chochi, Takashi Ichikura, Manabu Kinoshita, Takashi Majima, Nariyoshi Shinomiya, Hironori Tsujimoto, Toshinobu Kawabata, Hidekazu Sugasawa, Satoshi Ono, Shuhji Seki, and Hidetaka Mochizuki
Clin Cancer Res 2008;14 2909-2917
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2909

Epigenetic Silencing of the Tetraspanin CD9 during Disease Progression in Multiple Myeloma Cells and Correlation with Survival
Elke De Bruyne, Tomas Jan Bos, Kewal Asosingh, Isabelle Vande Broek, Eline Menu, Els Van Valckenborgh, Peter Atadja, Valérie Coiteux, Xavier Leleu, Kris Thielemans, Ben Van Camp, Karin Vanderkerken, and Ivan Van Riet
Clin Cancer Res 2008;14 2918-2926
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2918

Detection of Copy Number Alterations in Metastatic Melanoma by a DNA Fluorescence In situ Hybridization Probe Panel and Array Comparative Genomic Hybridization: A Southwest Oncology Group Study (S9431)
Stephen R. Moore, Diane L. Persons, Jeffrey A. Sosman, Dolores Bobadilla, Victoria Bedell, David D. Smith, Sandra R. Wolman, Ralph J. Tuthill, Jim Moon, Vernon K. Sondak, and Marilyn L. Slovak
Clin Cancer Res 2008;14 2927-2935
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2927

Divergent Effects of Castration on Prostate Cancer in TRAMP Mice: Possible Implications for Therapy
Yao Tang, Linbo Wang, Olga Goloubeva, Mohammad Afnan Khan, Bin Zhang, and Arif Hussain
Clin Cancer Res 2008;14 2936-2943
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2936

Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node–Negative Breast Cancer
Gert G. Van den Eynden, Marcel Smid, Steven J. Van Laere, Cecile G. Colpaert, Ilse Van der Auwera, Trinh Xuan Bich, Peter van Dam, Michael A. den Bakker, Luc Y. Dirix, Eric A. Van Marck, Peter B. Vermeulen, and John A. Foekens
Clin Cancer Res 2008;14 2944-2952
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2944

Loss of Heterozygosity at the BRCA2 Locus Detected by Multiplex Ligation-Dependent Probe Amplification is Common in Prostate Cancers from Men with a Germline BRCA2 Mutation
Amber J. Willems, Sarah-Jane Dawson, Hema Samaratunga, Alessandro De Luca, Yoland C. Antill, John L. Hopper, Heather J. Thorne, and and kConFab Investigators
Clin Cancer Res 2008;14 2953-2961
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2953

Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis
Pingyu Zhang, Yanwen Yang, Patrick A. Zweidler-McKay, and Dennis P.M. Hughes
Clin Cancer Res 2008;14 2962-2969
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2962

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Imaging, Diagnosis, Prognosis
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Imaging Bone and Soft Tissue Tumors with the Proliferation Marker [18F]Fluorodeoxythymidine
Andreas K. Buck, Ken Herrmann, Christian Meyer zum Büschenfelde, Malik E. Juweid, Mark Bischoff, Gerhard Glatting, Gregor Weirich, Peter Möller, Hans-Jürgen Wester, Klemens Scheidhauer, Tobias Dechow, Christian Peschel, Markus Schwaiger, and Sven N. Reske
Clin Cancer Res 2008;14 2970-2977
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2970

Novel Glioblastoma Markers with Diagnostic and Prognostic Value Identified through Transcriptome Analysis
Sreekanth P. Reddy, Ramona Britto, Katyayni Vinnakota, Hebbar Aparna, Hari Kishore Sreepathi, Balaram Thota, Arpana Kumari, B.M. Shilpa, M. Vrinda, Srikantha Umesh, Cini Samuel, Mitesh Shetty, Ashwani Tandon, Paritosh Pandey, Sridevi Hegde, A.S. Hegde, Anandh Balasubramaniam, B.A. Chandramouli, Vani Santosh, Paturu Kondaiah, Kumaravel Somasundaram, and M.R. Satyanarayana Rao
Clin Cancer Res 2008;14 2978-2987
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2978

Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort
Ben S. Wittner, Dennis C. Sgroi, Paula D. Ryan, Tako J. Bruinsma, Annuska M. Glas, Anitha Male, Sonika Dahiya, Karleen Habin, Rene Bernards, Daniel A. Haber, Laura J. Van’t Veer, and Sridhar Ramaswamy
Clin Cancer Res 2008;14 2988-2993
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2988

Inverse Association between Raf Kinase Inhibitory Protein and Signal Transducers and Activators of Transcription 3 Expression in Gastric Adenocarcinoma Patients: Implications for Clinical Outcome
Devasis Chatterjee, Edmond Sabo, Rosemarie Tavares, and Murray B. Resnick
Clin Cancer Res 2008;14 2994-3001
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/2994

Translocations Involving the Immunoglobulin Heavy Chain Gene Locus Predict Better Survival in Gastric Diffuse Large B-Cell Lymphoma
Shotaro Nakamura, Hongtao Ye, Chris M. Bacon, Alison Goatly, Hongxiang Liu, Lucy Kerr, Alison H. Banham, Berthold Streubel, Takashi Yao, Masazumi Tsuneyoshi, Antonella Savio, Morishige Takeshita, Peggy Dartigues, Agnès Ruskoné-Fourmestraux, Takayuki Matsumoto, Mitsuo Iida, and Ming-Qing Du
Clin Cancer Res 2008;14 3002-3010
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3002

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies
Maryla Krajewska, Shinichi Kitada, Jane N. Winter, Daina Variakojis, Alan Lichtenstein, Dayong Zhai, Michael Cuddy, Xianshu Huang, Frederic Luciano, Cheryl H. Baker, Hoguen Kim, Eunah Shin, Susan Kennedy, Allen H. Olson, Andrzej Badzio, Jacek Jassem, Ivo Meinhold-Heerlein, Michael J. Duffy, Aaron D. Schimmer, Ming Tsao, Ewan Brown, Anne Sawyers, Michael Andreeff, Dan Mercola, Stan Krajewski, and John C. Reed
Clin Cancer Res 2008;14 3011-3021
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3011

Impact of Insulin-Like Growth Factor Type 1 Receptor, Epidermal Growth Factor Receptor, and HER2 Expressions on Outcomes of Patients with Gastric Cancer
Junichi Matsubara, Yasuhide Yamada, Yoshinori Hirashima, Daisuke Takahari, Natsuko T. Okita, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, and Tadakazu Shimoda
Clin Cancer Res 2008;14 3022-3029
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3022

Vascular Endothelial Growth Factor Expression in Ovarian Cancer: A Model for Targeted Use of Novel Therapies?
Timothy J. Duncan, Ahmad Al-Attar, Phil Rolland, Ian V. Scott, Suha Deen, David T.Y. Liu, Ian Spendlove, and Lindy G. Durrant
Clin Cancer Res 2008;14 3030-3035
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3030

N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[18F]Fluorobenzyl-L-Cysteine, [18F]DCFBC: A New Imaging Probe for Prostate Cancer
Ronnie C. Mease, Crystal L. Dusich, Catherine A. Foss, Hayden T. Ravert, Robert F. Dannals, Jurgen Seidel, Andrew Prideaux, James J. Fox, George Sgouros, Alan P. Kozikowski, and Martin G. Pomper
Clin Cancer Res 2008;14 3036-3043
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3036

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Cancer Therapy: Clinical
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Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies
Raanan Berger, Rinat Rotem-Yehudar, Gideon Slama, Shimon Landes, Abraham Kneller, Merav Leiba, Maya Koren-Michowitz, Avichai Shimoni, and Arnon Nagler
Clin Cancer Res 2008;14 3044-3051
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3044

Clinical and Biological Effects of Neoadjuvant Sargramostim and Thalidomide in Patients with Locally Advanced Prostate Carcinoma
Jorge A. Garcia, Eric A. Klein, Cristina Magi-Galluzzi, Paul Elson, Pierre Triozzi, and Robert Dreicer
Clin Cancer Res 2008;14 3052-3059
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3052

Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma
James L. Gulley, Philip M. Arlen, Kwong-Yok Tsang, Junko Yokokawa, Claudia Palena, Diane J. Poole, Cinzia Remondo, Vittore Cereda, Jacquin L. Jones, Mary P. Pazdur, Jack P. Higgins, James W. Hodge, Seth M. Steinberg, Herbert Kotz, William L. Dahut, and Jeffrey Schlom
Clin Cancer Res 2008;14 3060-3069
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3060

Tamoxifen and Aromatase Inhibitors Differentially Affect Vascular Endothelial Growth Factor and Endostatin Levels in Women with Breast Cancer
Chris E. Holmes, Joe C. Huang, Thomas R. Pace, Alan B. Howard, and Hyman B. Muss
Clin Cancer Res 2008;14 3070-3076
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3070

Phase II Trial of Tipifarnib as Maintenance Therapy in First Complete Remission in Adults with Acute Myelogenous Leukemia and Poor-Risk Features
Judith E. Karp, B. Douglas Smith, Ivana Gojo, Jeffrey E. Lancet, Jacqueline Greer, Maureen Klein, Larry Morris, Mark J. Levis, Steven D. Gore, John J. Wright, and Elizabeth Garrett-Mayer
Clin Cancer Res 2008;14 3077-3082
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3077

Efficacy of Gemcitabine in Patients with Non–Small Cell Lung Cancer According to Promoter Polymorphisms of the Ribonucleotide Reductase M1 Gene
Soo-Ok Kim, Ju-Yeon Jeong, Mi-Ran Kim, Hyun-Ju Cho, Jin-Yung Ju, Yong-Soo Kwon, In-Jae Oh, Kyu-Sik Kim, Yu-Il Kim, Sung-Chul Lim, and Young-Chul Kim
Clin Cancer Res 2008;14 3083-3088
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3083

Phase I Study and Preliminary Pharmacology of the Novel Innate Immune Modulator rBBX-01 in Gynecologic Cancers
Janet S. Rader, Charles F. Aylsworth, David A. Juckett, David G. Mutch, Matthew A. Powell, Lynne Lippmann, and Nikolay V. Dimitrov
Clin Cancer Res 2008;14 3089-3097
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3089

Postoperative Adjuvant Dendritic Cell–Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme
Steven De Vleeschouwer, Steffen Fieuws, Stefan Rutkowski, Frank Van Calenbergh, Johannes Van Loon, Jan Goffin, Raf Sciot, Guido Wilms, Philippe Demaerel, Monika Warmuth-Metz, Niels Soerensen, Johannes E.A. Wolff, Sabine Wagner, Eckhart Kaempgen, and Stefaan W. Van Gool
Clin Cancer Res 2008;14 3098-3104
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3098

Phase I Clinical and Pharmacokinetic Study of Plitidepsin as a 1-Hour Weekly Intravenous Infusion in Patients with Advanced Solid Tumors
Miguel A. Izquierdo, Angela Bowman, Margarita García, Duncan Jodrell, Marisa Martinez, Beatriz Pardo, Javier Gómez, José A. López-Martin, José Jimeno, José R. Germá, and John F. Smyth
Clin Cancer Res 2008;14 3105-3112
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3105

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Cancer Therapy: Preclinical
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Evaluation of the In vitro and In vivo Antitumor Activity of Histone Deacetylase Inhibitors for the Therapy of Retinoblastoma
Clifton Lee Dalgard, Kurtis R. Van Quill, and Joan M. O’Brien
Clin Cancer Res 2008;14 3113-3123
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3113

Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy
Jon O. Curwen, Helen L. Musgrove, Jane Kendrew, Graham H.P. Richmond, Donald J. Ogilvie, and Stephen R. Wedge
Clin Cancer Res 2008;14 3124-3131
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3124

Histone Deacetylase Inhibition and Blockade of the Glycolytic Pathway Synergistically Induce Glioblastoma Cell Death
Vivian Egler, Serdar Korur, Mike Failly, Jean-Louis Boulay, Roland Imber, Maria M. Lino, and Adrian Merlo
Clin Cancer Res 2008;14 3132-3140
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3132

Interaction of Imatinib with Human Organic Ion Carriers
Shuiying Hu, Ryan M. Franke, Kelly K. Filipski, Chaoxin Hu, Shelley J. Orwick, Ernst A. de Bruijn, Herman Burger, Sharyn D. Baker, and Alex Sparreboom
Clin Cancer Res 2008;14 3141-3148
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3141

A BTB/POZ Gene, NAC-1, a Tumor Recurrence–Associated Gene, as a Potential Target for Taxol Resistance in Ovarian Cancer
Masako Ishibashi, Kentaro Nakayama, Shamima Yeasmin, Atsuko Katagiri, Kouji Iida, Naomi Nakayama, Manabu Fukumoto, and Kohji Miyazaki
Clin Cancer Res 2008;14 3149-3155
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3149

Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma
Justin Kline, Ian E. Brown, Yuan-Yuan Zha, Christian Blank, John Strickler, Harald Wouters, Long Zhang, and Thomas F. Gajewski
Clin Cancer Res 2008;14 3156-3167
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3156

Aspirin Sensitizes Cancer Cells to TRAIL–Induced Apoptosis by Reducing Survivin Levels
Meiling Lu, Anne Strohecker, Feng Chen, Toni Kwan, Joshua Bosman, V. Craig Jordan, and Vincent L. Cryns
Clin Cancer Res 2008;14 3168-3176
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3168

Chemopreventive Efficacy of Inositol Hexaphosphate against Prostate Tumor Growth and Progression in TRAMP Mice
Komal Raina, Subapriya Rajamanickam, Rana P. Singh, and Rajesh Agarwal
Clin Cancer Res 2008;14 3177-3184
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3177

Pretreatment with Cisplatin Enhances E7-Specific CD8+ T-Cell–Mediated Antitumor Immunity Induced by DNA Vaccination
Chih-Wen Tseng, Chien-Fu Hung, Ronald D. Alvarez, Cornelia Trimble, Warner K. Huh, Daejin Kim, Chi-Mu Chuang, Cheng-Tao Lin, Ya-Chea Tsai, Liangmei He, Archana Monie, and T-C. Wu
Clin Cancer Res 2008;14 3185-3192
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3185

Modulation of Drug Resistance in Ovarian Adenocarcinoma by Enhancing Intracellular Ceramide Using Tamoxifen-Loaded Biodegradable Polymeric Nanoparticles
Harikrishna Devalapally, Zhenfeng Duan, Michael V. Seiden, and Mansoor M. Amiji
Clin Cancer Res 2008;14 3193-3203
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3193

Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors
Narasimhan P. Agaram, Michael P. Laquaglia, Berrin Ustun, Tianhua Guo, Grace C. Wong, Nicholas D. Socci, Robert G. Maki, Ronald P. DeMatteo, Peter Besmer, and Cristina R. Antonescu
Clin Cancer Res 2008;14 3204-3215
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3204

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Cancer Prevention and Susceptibility
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A Functional Epidermal Growth Factor (EGF) Polymorphism, EGF Serum Levels, and Esophageal Adenocarcinoma Risk and Outcome
Michael Lanuti, Geoffrey Liu, Jonathan M. Goodwin, Rihong Zhai, Bryan C. Fuchs, Kofi Asomaning, Li Su, Norman S. Nishioka, Kenneth K. Tanabe, and David C. Christiani
Clin Cancer Res 2008;14 3216-3222
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3216

VDR and SRD5A2 Polymorphisms Combine to Increase Risk for Prostate Cancer in Both Non–Hispanic White and Hispanic White Men
Kathleen C. Torkko, Adrie van Bokhoven, Phoung Mai, Joke Beuten, Ivana Balic, Tim E. Byers, John E. Hokanson, Jill M. Norris, Anna E. Barón, M. Scott Lucia, Ian M. Thompson, and Robin J. Leach
Clin Cancer Res 2008;14 3223-3229
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3223

Functional Variants in Cell Death Pathway Genes and Risk of Pancreatic Cancer
Ming Yang, Tong Sun, Li Wang, Dianke Yu, Xuemei Zhang, Xiaoping Miao, Junniao Liu, Dan Zhao, Hui Li, Wen Tan, and Dongxin Lin
Clin Cancer Res 2008;14 3230-3236
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/10/3230