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SMOKING’S EFFECTS ON GENES MAY PLAY A ROLE IN LUNG CANCER DEVELOPMENT AND SURVIVAL

U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Cancer Institute (NCI) <http://www.nci.nih.gov/>
Tuesday, February 19, 2008, 8:00 p.m. EST
Contacts: NCI Office of Media Relations:
301-496-6641
ncipressofficers@mail.nih.gov

Smoking plays a role in lung cancer development, and now scientists have shown that smoking also affects the way genes are expressed, leading to alterations in cell division and regulation of immune response. Notably, some of the changes in gene expression persisted in people who had quit smoking many years earlier. These findings by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, appeared in the Feb. 20, 2008, issue of “PLoS ONE”.

“Smoking, we are well aware, is the leading cause of lung cancer worldwide,” said NCI Director John E. Niederhuber, M.D. “Yet, a mechanistic understanding of the effects of smoking on the cells of the lung remains incomplete. This study demonstrates an important piece of this complicated puzzle. Greater understanding of the genetic alterations that occur with smoking should provide greater insight into the development of cellular targets for treating, and possibly preventing, lung cancer.”

“We were able to look at actual lung tissue, tumor and non-tumor, taking into account the differences by gender, verifying the smoking status by measuring levels of cotinine, a metabolite of nicotine, in participants’ plasma, and confirming results in independent samples,” said Maria Teresa Landi, M.D., Ph.D., in NCI’s Division of Cancer Epidemiology and Genetics, the first author of the study report.

To investigate the effects of smoking on gene activity in lung tissue, the researchers examined the gene expression profiles - patterns of gene activity - in early-stage lung tumors and non-tumor lung tissue of smokers, former smokers, and people who had never smoked cigarettes. Gene expression was measured in 58 fresh-frozen tumor and 49 fresh-frozen non-tumor samples from 74 participants of the Environment And Genetics in Lung cancer Etiology (EAGLE) study, a large lung cancer study that was conducted in the Lombardy region of Italy. Adenocarcinoma tumor samples were evaluated in this study because adenocarcinoma is the most common type of lung cancer, and it occurs in both smokers and people with no history of smoking. The participants were 44 to 79 years of age, and 28 were current smokers, 26 were former smokers, and 20 had never smoked. The researchers also obtained detailed medical information about the participants (for example, whether individuals had previous lung diseases or chemotherapy) and biochemically confirmed participants’ smoking status.

Using microarray techniques, which allow researchers to look at the activity of thousands of genes simultaneously, they identified 135 genes that were differently expressed in tumors of smokers vs. people who had never smoked. Among these genes, 81 showed decreased expression and 54 showed increased expression in tumor tissue.

Most of the genes showing significantly increased expression, e.g., TTK, NEK2, and PRC1, are involved in cell cycle regulation and mitosis. The cell cycle is a step-wise sequence of events in which a cell grows and ultimately divides to produce two progeny, or daughter, cells. During the cell cycle, the chromosomes of the parent cell are duplicated and then, in a step called mitosis, divided equally between the daughter cells, ensuring that each daughter cell inherits a complete set of chromosomes. The cell apparatus responsible for the proper division of chromosomes is called the mitotic spindle.

“Our results indicate that smoking causes changes in genes that control mitotic spindle formation,” said Jin Jen, Ph.D., in NCI’s Center for Cancer Research, a senior author of the study report. “Irregular division of chromosomes and chromosome instability are two common abnormalities that occur in cancer cells when the chromosomes do not separate equally between the daughter cells. Therefore, changes in the mitotic process are very relevant in the development of cancer.” Several of the identified genes have been suggested in the past as potential targets for cancer treatment.

The researchers also found similar expression of many genes among current smokers and former smokers in tumor tissue. Several of these genes, such as STOM, SSX2IP, and APLP2, remained altered in participants who had quit smoking more than 20 years before the study. Therefore, smoking seems to cause long-lasting changes in gene expression, which can contribute to lung cancer development long after cessation.

Looking at non-tumor lung tissues, the team found decreased activity for 73 genes and increased activity for 25 genes in current smokers. The genes most affected by smoking play a role in immune response-related processes, possibly as a lung defense mechanism against the acute toxic effects of smoking. However, non-tumor tissues seem to be able to recover from the effects of smoking. The researchers did not identify significant changes in the immune response-related genes in former smokers.

To gain a better understanding of the impact of smoking-related changes in gene expression on lung cancer survival, the researchers compared the overall gene expression smoking profile in lung tumor and non-tumor tissues with survival. They found that the altered expression of the cell cycle-related genes NEK2 and TTK in non-tumor tissues was associated with a three-fold increased risk of lung cancer mortality in smokers.

“Our data provide clues on how cigarette smoking affects the development of lung cancer, indicating that the very same mitotic genes known to be involved in cancer development are altered by smoking and affect survival. More studies are needed to confirm that the gene expression changes are due to smoking and affect tumor development or progression,” said Landi. “If confirmed, these genes could become important targets for preventing and treating lung cancer.”

About 90 percent of lung cancer deaths among men and almost 80 percent of lung cancer deaths among women can be attributed to smoking. In 2006, approximately 20.8 percent of U.S. adults were cigarette smokers. Cigarette smoking remains the leading preventable cause of death in the United States, causing an estimated 438,000 deaths, or about one out of every five deaths each year.

For more information on research in Dr. Landi’s group, please go to <http://dceg.cancer.gov/about/staff-bios/landi-maria>.

For more information on research in Dr. Jen’s lab, please go to <http://ccr.cancer.gov/staff/staff.asp\?profileid=5542>.

For more information about the EAGLE study, please go to <http://dceg.cancer.gov/eagle>.

For more information about cancer, please visit the NCI website at <http://www.cancer.gov/>, or call NCI’s Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).

The National Institutes of Health (NIH) - The Nation’s Medical Research Agency - is comprised of 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary Federal agency for conducting and supporting basic, clinical, and translational medical research, and investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <www.nih.gov>.
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REFERENCE:
Landi MT, Dracheva T, Rotunno M, Figueroa, JD, Liu H, Dasgupta A, Mann FE, Fukuoka J, Hames M, Bergen AW, Murphy SE, Yang P, Pesatori AC, Consonni D, Bertazzi PA, Wacholder S, Shih JH, Caporaso NE, and Jen J. February 2008. Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival. “PLoS ONE”. Vol. 3, No. 2.

This NIH News Release is available online at:
<http://www.nih.gov/news/health/feb2008/nci-19.htm>.

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Cancer Newsletter  |  Week of February 17      In This Issue:  Most Docs Prescribe Cancer Treatment They’d Want  Cancer Patient? Consider a Support Group  PET Scans Are No Fun — Hard Time Emotionally, Help! Today’s Top Story: A Cancer Diagnosis — What Comes Next? When you discover you have cancer, your whole world changes. You suddenly find yourself in the fight of your life. Is there any way to strengthen yourself, both in body and mind, to prepare for what comes next? See what the experts suggest. Also See:  How Cancer Affects a Family  Total Cancer Care — Fight Back With Everything  Preventing Chemotherapy Hearing Loss Health News Headlines ‘08 Election & Your Health: WebMD Compares the Candidates Most Docs Prescribe Cancer Treatment They’d Want If you’re faced with a diagnosis of cancer, it may be worthwhile to ask your cancer doctor what he or she would do in your shoes. See why. More Headlines You Shouldn’t Miss: The Big Picture  Will Tobacco Kill 1 Billion This Century?  Worse Cancer Diagnosis for Uninsured  Overweight, Obesity Linked to Cancer Breast Cancer News  3 Breast Cancer Gene Tests Promising Prostate Cancer News  Prostate Biopsies Help Tailor Treatment  Test for Prostate Cancer in the Works  Statins, NSAIDs vs. Prostate Cancer  Finding the Right Prostate Cancer Diet Editor’s Picks Cancer Patient? Consider a Support Group If you’re seeking a social support network outside your immediate family, a support group may be just what the doctor ordered. Learn more. Also See:  Coping With Cancer  Thyroid Cancer: Just the Facts More Hot Topics on WebMD  4 New High Tech Tools to Combat Diabetes  Ready to Quit Smoking? See These Great New Strategies Members Are Talking PET Scans Are No Fun — Hard Time Emotionally, Help! This member has his annual PET scan and he doesn’t want to go. Been there? He needs your support.

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Breast Cancer Newsletter  |  Week of February 17      In This Issue:  Worse Cancer Outcomes for Uninsured  Surviving Breast Cancer  Member Commentary: Hair Today, Gone Tomorrow Today’s Top Story: Where Fear Runs Too High: A Calming Voice? A study finds far too many women live in fear despite successful treatment for DCIS, an early, noninvasive breast cancer. Also See:  Breast Cancer Prevention  Obesity Linked to Breast Cancer  Most Breast Cancer Web Data Reliable  Crocs: Healthy Shoes or Just Comfy?  Do You Know All Your Treatment Options? Health News Headlines Drug Safety Alert: Fentanyl Pain Patches Recalled Worse Cancer Outcomes for Uninsured Researchers find that Americans without health insurance are diagnosed with cancer at later, more advanced stages than patients with private health insurance. Cancer Gene Tests Show Promise Researchers say three breast cancer gene tests may provide insight on recurrence risk and chemotherapy treatment. Also See:  Obesity Linked to Breast Cancer  Test Can Detect Early Ovarian Cancer  Americans Split on Socialized Medicine Editor’s Picks Surviving Breast Cancer After cancer, a woman finds a way to be whole again, putting herself back together with love, exercise, and dog slobber. Also See:  Fight Breast Cancer at Every Meal  Your Healthy Breast To Do List  Stop Procrastinating Right Now Members Are Talking Hair Today, Gone Tomorrow A cancer patient whose hair was getting thin from Tamoxifen therapy didn’t know she could get a wig from the American Cancer Society until she asked for help. She was glad she did. Candles of Hope A member writes about a Web site that lights candles of hope all over the world. Early Breast Cancer: Understanding Recurrence Risk Recurrence is the term used to describe the return of cancer following initial treatment. It’s perfectly normal to feel some fear about the possibility that breast cancer could recur. What can you do? Fight fear with information.

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As the advances in cancer treatment continue to lead to greater survivorship rates, many patients, especially those of childhood cancers, experience a new set of challenges. These include a greater risk of secondary cancers, limited access to adequate follow-up care, and cognitive or psychosocial problems. Fortunately, Congresswomen Hilda L. Solis and Mary Bono Mack have introduced the Pediatric, Adolescent and Young Adult Cancer Survivorship and Quality of Life Act (H.R. 4450) which is aimed at enhancing the delivery of follow-up care, increase education and training for health care providers, and expand research to improve the lives of childhood cancer survivors.

The Leukemia & Lymphoma Society (LLS) asks that you urge your representative to cosponsor this legislation by visiting http://action.lls.org. Please, make sure that your Member of Congress supports this important step in ensuring that cancer survivors can maintain a high quality of life.

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The below Table of Contents is available online at: http://clincancerres.aacrjournals.org/content/vol14/issue4/?etoc

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Molecular Pathways
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Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma
Silvin Bakalian, Jean-Claude Marshall, Patrick Logan, Dana Faingold, Shawn Maloney, Sebastian Di Cesare, Claudia Martins, Bruno F. Fernandes, and Miguel N. Burnier, Jr.
Clin Cancer Res 2008;14 951-956

Article

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Perspective
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Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments
Alba A. Brandes, Enrico Franceschi, Alicia Tosoni, Monika E. Hegi, and Roger Stupp
Clin Cancer Res 2008;14 957-960

Article

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Reviews
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Identifying Breast Cancer Druggable Oncogenic Alterations: Lessons Learned and Future Targeted Options
Alberto Ocaña and Atanasio Pandiella
Clin Cancer Res 2008;14 961-970

Article

Medulloblastoma: From Molecular Pathology to Therapy
Alessandra Rossi, Valentina Caracciolo, Giuseppe Russo, Krzysztof Reiss, and Antonio Giordano
Clin Cancer Res 2008;14 971-976

Article

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Human Cancer Biology
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ETV6-NCOA2: A Novel Fusion Gene in Acute Leukemia Associated with Coexpression of T-Lymphoid and Myeloid Markers and Frequent NOTCH1 Mutations
Sabine Strehl, Karin Nebral, Margit König, Jochen Harbott, Herbert Strobl, Richard Ratei, Stephanie Struski, Bella Bielorai, Michel Lessard, Martin Zimmermann, Oskar A. Haas, and Shai Izraeli
Clin Cancer Res 2008;14 977-983

Article

Nuclear Factor-Y and Epstein Barr Virus in Nasopharyngeal Cancer
Marie C. Chia, Abby Leung, Tiffany Krushel, Nehad M. Alajez, Kwok W. Lo, Pierre Busson, Henry J. Klamut, Carlo Bastianutto, and Fei-Fei Liu
Clin Cancer Res 2008;14 984-994

Article

Differential Wnt Pathway Gene Expression and E-Cadherin Truncation in Sporadic Colorectal Cancers with and without Microsatellite Instability
Paloma Ortega, Alberto Morán, Carmen de Juan, Cristina Frías, Susana Hernández, Jose-Antonio López-Asenjo, Andrés Sánchez-Pernaute, Antonio Torres, Pilar Iniesta, and Manuel Benito
Clin Cancer Res 2008;14 995-1001

Article

Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression
Vyomesh Patel, Brian L. Hood, Alfredo A. Molinolo, Norman H. Lee, Thomas P. Conrads, John C. Braisted, David B. Krizman, Timothy D. Veenstra, and J. Silvio Gutkind
Clin Cancer Res 2008;14 1002-1014

Article

High-Resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-Based Comparative Genomic Hybridization
Kiran K. Mantripragada, Gillian Spurlock, Lan Kluwe, Nadia Chuzhanova, Rosalie E. Ferner, Ian M. Frayling, Jan P. Dumanski, Abhijit Guha, Victor Mautner, and Meena Upadhyaya
Clin Cancer Res 2008;14 1015-1024

Article

Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor
Ryouichi Tsunedomi, Norio Iizuka, Takao Tamesa, Kazuhiko Sakamoto, Takashi Hamaguchi, Hideaki Somura, Mamoru Yamada, and Masaaki Oka
Clin Cancer Res 2008;14 1025-1031

Article

Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer
Junko Yokokawa, Vittore Cereda, Cinzia Remondo, James L. Gulley, Philip M. Arlen, Jeffrey Schlom, and Kwong Y. Tsang
Clin Cancer Res 2008;14 1032-1040

Article

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Imaging, Diagnosis, Prognosis
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Reduced hGC-1 Protein Expression Is Associated with Malignant Progression of Colon Carcinoma
Wenli Liu, Yueqin Liu, Jianqiong Zhu, Elizabeth Wright, Ivan Ding, and Griffin P. Rodgers
Clin Cancer Res 2008;14 1041-1049

Article

Analysis of Integrin β4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance
Shaolei Lu, Karl Simin, Ashraf Khan, and Arthur M. Mercurio
Clin Cancer Res 2008;14 1050-1058

Article

Thymidylate Synthase Expression in Gastroenteropancreatic and Pulmonary Neuroendocrine Tumors
Paolo Ceppi, Marco Volante, Anna Ferrero, Luisella Righi, Ida Rapa, Rosj Rosas, Alfredo Berruti, Luigi Dogliotti, Giorgio V. Scagliotti, and Mauro Papotti
Clin Cancer Res 2008;14 1059-1064

Article

Diagnostic Markers for Early Detection of Ovarian Cancer
Irene Visintin, Ziding Feng, Gary Longton, David C. Ward, Ayesha B. Alvero, Yinglei Lai, Jeannette Tenthorey, Aliza Leiser, Ruben Flores-Saaib, Herbert Yu, Masoud Azori, Thomas Rutherford, Peter E. Schwartz, and Gil Mor
Clin Cancer Res 2008;14 1065-1072

Article

Epithelial Human Leukocyte Antigen-DR Expression Predicts Reduced Recurrence Rates and Prolonged Survival in Rectal Cancer Patients
Elza C. de Bruin, Cornelis J.H. van de Velde, J. Han J.M. van Krieken, Corrie A.M. Marijnen, and Jan Paul Medema
Clin Cancer Res 2008;14 1073-1079

Article

Identification of Cystatin B as a Potential Serum Marker in Hepatocellular Carcinoma
Mi-Jin Lee, Gyung-Ran Yu, Seon-Hwa Park, Baik-Hwan Cho, Jong-Seong Ahn, Hae-Joon Park, Eun-Young Song, and Dae-Ghon Kim
Clin Cancer Res 2008;14 1080-1089

Article

Effects of Common Germ-Line Genetic Variation in Cell Cycle Genes on Ovarian Cancer Survival
Honglin Song, Estrid Hogdall, Susan J. Ramus, Richard A. DiCioccio, Claus Hogdall, Lydia Quaye, Valerie McGuire, Alice S. Whittemore, Mitul Shah, David Greenberg, Douglas F. Easton, Susanne Kruger Kjaer, Paul D.P. Pharoah, and Simon A. Gayther
Clin Cancer Res 2008;14 1090-1095

Article

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Cancer Therapy: Clinical
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Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
Mark R. Albertella, Paul M. Loadman, Philip H. Jones, Roger M. Phillips, Roy Rampling, Neil Burnet, Chris Alcock, Alan Anthoney, Egils Vjaters, Chris R. Dunk, Peter A. Harris, Alvin Wong, Alshad S. Lalani, and Chris J. Twelves
Clin Cancer Res 2008;14 1096-1104

Article

Phase I Clinical Study of Atacicept in Patients with Relapsed and Refractory B-Cell Non–Hodgkin’s Lymphoma
Stephen M. Ansell, Thomas E. Witzig, David J. Inwards, Luis F. Porrata, Arnaud Ythier, Lee Ferrande, Ivan Nestorov, Todd DeVries, Stacey R. Dillon, Diana Hausman, and Anne J. Novak
Clin Cancer Res 2008;14 1105-1110

Article

A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors
Elizabeth Fox, John M. Maris, Brigitte C. Widemann, Wendy Goodspeed, Anne Goodwin, Marie Kromplewski, Molly E. Fouts, Diane Medina, Susan L. Cohn, Andrew Krivoshik, Anne E. Hagey, Peter C. Adamson, and Frank M. Balis
Clin Cancer Res 2008;14 1111-1115

Article

Phase I Clinical and Pharmacokinetic Study of Kahalalide F Administered Weekly as a 1-Hour Infusion to Patients with Advanced Solid Tumors
Beatriz Pardo, Luis Paz-Ares, Josep Tabernero, Eva Ciruelos, Margarita García, Ramón Salazar, Ana López, María Blanco, Antonio Nieto, José Jimeno, Miguel Ángel Izquierdo, and José Manuel Trigo
Clin Cancer Res 2008;14 1116-1123

Article

Phase I Trial of VNP40101M (Cloretazine) in Children with Recurrent Brain Tumors: A Pediatric Brain Tumor Consortium Study
Sridharan Gururangan, Christopher D. Turner, Clinton F. Stewart, Melinda O’Shaughnessy, Mehmet Kocak, Tina Young Poussaint, Peter C. Phillips, Stewart Goldman, Roger Packer, Ian F. Pollack, Susan M. Blaney, Verena Karsten, Stanton L. Gerson, James M. Boyett, Henry S. Friedman, and Larry E. Kun
Clin Cancer Res 2008;14 1124-1130

Article

A Phase I and Pharmacokinetic Trial of Erlotinib in Combination with Weekly Docetaxel in Patients with Taxane-Naive Malignancies
E. Gabriela Chiorean, Jennifer M. Porter, Anne E. Foster, Amal S.H. Al Omari, Christy A. Yoder, Karen L. Fife, R. Matthew Strother, Daryl J. Murry, Menggang Yu, David R. Jones, and Christopher J. Sweeney
Clin Cancer Res 2008;14 1131-1137

Article

Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade
Jayne S. Sutherland, Lisa Spyroglou, Jennifer L. Muirhead, Tracy S. Heng, Adria Prieto-Hinojosa, H. Miles Prince, Ann P. Chidgey, Anthony P. Schwarer, and Richard L. Boyd
Clin Cancer Res 2008;14 1138-1149

Article

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Cancer Therapy: Preclinical
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Methylseleninic Acid Enhances Taxane Drug Efficacy against Human Prostate Cancer and Down-Regulates Antiapoptotic Proteins Bcl-XL and Survivin
Hongbo Hu, Guang-xun Li, Lei Wang, Jennifer Watts, Gerald F. Combs, Jr., and Junxuan Lü
Clin Cancer Res 2008;14 1150-1158

Article

Enhancement of Antitumor Radiation Efficacy and Consistent Induction of the Abscopal Effect in Mice by ECI301, an Active Variant of Macrophage Inflammatory Protein-1
Kenshiro Shiraishi, Yoshiro Ishiwata, Keiichi Nakagawa, Shoji Yokochi, Chiho Taruki, Teruo Akuta, Kuni Ohtomo, Kouji Matsushima, Takuya Tamatani, and Shiro Kanegasaki
Clin Cancer Res 2008;14 1159-1166

Article

Suppression of Peutz-Jeghers Polyposis by Targeting Mammalian Target of Rapamycin Signaling
Chongjuan Wei, Christopher I. Amos, Nianxiang Zhang, Xiaopei Wang, Asif Rashid, Cheryl L. Walker, Richard R. Behringer, and Marsha L. Frazier
Clin Cancer Res 2008;14 1167-1171

Article

Targeting the Phosphoinositide 3-Kinase Isoform p110 Impairs Growth and Survival in Neuroblastoma Cells
Danielle Boller, Alexander Schramm, Kathrin T. Doepfner, Tarek Shalaby, André O. von Bueren, Angelika Eggert, Michael A. Grotzer, and Alexandre Arcaro
Clin Cancer Res 2008;14 1172-1181

Article

TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer
Nipun B. Merchant, Igor Voskresensky, Christopher M. Rogers, Bonnie LaFleur, Peter J. Dempsey, Ramona Graves-Deal, Frank Revetta, A. Coe Foutch, Mace L. Rothenberg, Mary K. Washington, and Robert J. Coffey
Clin Cancer Res 2008;14 1182-1191

Article

Trastuzumab Activates Allogeneic or Autologous Antibody-Dependent Cellular Cytotoxicity against Malignant Rhabdoid Tumor Cells and Interleukin-2 Augments the Cytotoxicity
Yoshiki Katsumi, Yasumichi Kuwahara, Shinichi Tamura, Ken Kikuchi, Osamu Otabe, Kunihiko Tsuchiya, Tomoko Iehara, Hiroshi Kuroda, Hajime Hosoi, and Tohru Sugimoto
Clin Cancer Res 2008;14 1192-1199

Article

Effect of Trans-2,3-Dimethoxycinnamoyl Azide on Enhancing Antitumor Activity of Romidepsin on Human Bladder Cancer
Jinhai Fan, Jennifer Stanfield, Yi Guo, Jose A. Karam, Eugene Frenkel, Xiankai Sun, and Jer-Tsong Hsieh
Clin Cancer Res 2008;14 1200-1207

Article

Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors
Euan C. Ramsay, Malathi Anantha, Jason Zastre, Marieke Meijs, Jet Zonderhuis, Dita Strutt, Murray S. Webb, Dawn Waterhouse, and Marcel B. Bally
Clin Cancer Res 2008;14 1208-1217

Article

Oncolytic Efficacy of Recombinant Vesicular Stomatitis Virus and Myxoma Virus in Experimental Models of Rhabdoid Tumors
Yushui Wu, Xueqing Lun, Hongyuan Zhou, Limei Wang, Beichen Sun, John C. Bell, John W. Barrett, Grant McFadden, Jaclyn A. Biegel, Donna L. Senger, and Peter A. Forsyth
Clin Cancer Res 2008;14 1218-1227

Article

Tumor-Selective Replication of an Oncolytic Adenovirus Carrying Oct-3/4 Response Elements in Murine Metastatic Bladder Cancer Models
Chao-Liang Wu, Gia-Shing Shieh, Chao-Ching Chang, Yi-Te Yo, Chih-Hau Su, Meng-Ya Chang, Yin-Hui Huang, Pensee Wu, and Ai-Li Shiau
Clin Cancer Res 2008;14 1228-1238

Article

Yeast-Derived β-Glucan Augments the Therapeutic Efficacy Mediated by Anti–Vascular Endothelial Growth Factor Monoclonal Antibody in Human Carcinoma Xenograft Models
Carolina Salvador, Bing Li, Richard Hansen, Daniel E. Cramer, Maiying Kong, and Jun Yan
Clin Cancer Res 2008;14 1239-1247

Article

Honokiol, a Constituent of Oriental Medicinal Herb Magnolia officinalis, Inhibits Growth of PC-3 Xenografts In vivo in Association with Apoptosis Induction
Eun-Ryeong Hahm, Julie A. Arlotti, Stanley W. Marynowski, and Shivendra V. Singh
Clin Cancer Res 2008;14 1248-1257

Article

Preclinical Toxicity, Toxicokinetics, and Antitumoral Efficacy Studies of DTS-201, a Tumor-Selective Peptidic Prodrug of Doxorubicin
Denis Ravel, Vincent Dubois, Jérôme Quinonero, Florence Meyer-Losic, JeanPierre Delord, Philippe Rochaix, Céline Nicolazzi, Fabien Ribes, Catherine Mazerolles, Elise Assouly, Karine Vialatte, Inès Hor, Jonathan Kearsey, and André Trouet
Clin Cancer Res 2008;14 1258-1265

Article

Gefitinib Radiosensitizes Non–Small Cell Lung Cancer Cells by Suppressing Cellular DNA Repair Capacity
Toshimitsu Tanaka, Anupama Munshi, Colin Brooks, Jenny Liu, Marvette L. Hobbs, and Raymond E. Meyn
Clin Cancer Res 2008;14 1266-1273

Article

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Cancer Prevention and Susceptibility
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Molecular Risk Assessment for Breast Cancer Development in Patients with Ductal Hyperplasias
Indira Poola, Jessy Abraham, Josephine J. Marshalleck, Qingqi Yue, Vinatha B. Lokeshwar, George Bonney, and Robert L. DeWitty
Clin Cancer Res 2008;14 1274-1280

Article

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Corrections
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Correction: Article on Phosphatidylinositol 3-Kinase in Breast Cancer
Clin Cancer Res 2008;14 1281

Corrections

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Featured Story	FEBRUARY 2008
Dana-Farber installs new imaging equipment capable of completing scans faster The installation of a Toshiba CT (computed tomography) scanner in the Lank Radiology Department is one of the first milestones in a year-long project to update imaging technology services at Dana-Farber. Read more
News ‘Councils’ have offered ‘counsel’ for 10 years For the past decade, the Patient and Family Advisory Councils (PFAC) have left their mark throughout Dana-Farber, from improving patient services to helping design clinics to publishing Side by Side, a newsletter written by and for patients and families. Read more New picture of HIV-1’s protein jacket identifies attractive target for antibody-based vaccine By coaxing the HIV-1 protein to reveal a hidden portion of its protein coat, scientists at Dana-Farber and Harvard Medical School have provided a newly detailed picture of how protective, or so-called broadly neutralizing, antibodies block HIV-1 infection. Read more Dana-Farber launches online stores Show your pride for Dana-Farber by sporting an item from our online stores. Choose from dozens of products with the Dana-Farber, Jimmy Fund or an individual event logo. View online stores Survivor Story: A teen friendship flowers between hospital roommates When she became hospital roommates with Chelsie, who was the same age and had received the same diagnosis, Valerie Bradley learned that cancer can bring people together in a way nothing else can. Read her story
Save the Date Tuesday, February 12, 2008 Lymphedema Talks DFCI, Dana 100 Blum Resource Center 11 a.m. - 12 p.m. This educational session discusses lymphedema risks, causes and management. For more information or to register, please call (617) 632-2217. Friday, February 22, 2008 Side Effects of Treatment: Learn More About Blood Counts DFCI, Dana 100 Blum Resource Center 11 a.m. - 12 p.m. This education series is hosted by the Blum Resource Center and facilitated by a representative of the Patient/Family Education Department. To register and obtain further information, call (617) 632-2099. Thursday, March 6, 2008 Chefs Cooking for Hope Sip champagne, enjoy delicious food from Boston’s top chefs and help fight cancer at the Friends of Dana Farber’s 10th annual “Chefs Cooking for Hope.” More than 40 chefs, restaurants and caterers will serve their culinary specialties, including chef Kevin Crawley from Coriander, who is serving as honorary chair for the event. Purchase tickets Wednesday, March 26, 2008 Nordstrom Burlington Gala Join us at the grand opening of the new Nordstrom at Burlington Mall for an evening of fashion and fun to help raise vital funds for Dana-Farber. Enjoy an exciting fashion show complemented by cocktails, dinner and dessert buffets, musical entertainment and, of course, fabulous shopping. Learn more For more information To view all of our upcoming seminars, workshops, and fundraising events, go to our Event Calendar. Learn more

This Month:

February Spotlight: Integrative Therapies

Learn more about how integrative therapies can improve the quality of life of cancer patients, view related stories and videos, take our health quiz, and more. View Spotlight

Monthly health quiz

What is the leading cause of cancer-related death in women in the U.S.? Take the quiz

Nutrition tip and recipe of the month

Berries are a good source of Vitamin C and fiber as well as the phytonutrient ellagic acid, which may help slow the growth of cancer cells. Try Fruit Salsa and Cinnamon Chips.

Get the recipe
Ask the Nutritionist

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